tetano
Editor, Senior Moderator
Microbes Infect. 2016 Jul 7. pii: S1286-4579(16)30090-9. doi: 10.1016/j.micinf.2016.06.007. [Epub ahead of print]
[h=1]Mucosal delivery of a combination adjuvant comprising emulsified fine particles and LD-indolicidin enhances serological immunity to inactivated influenza virus.[/h] Huang MH[SUP]1[/SUP], Dai SH[SUP]2[/SUP], Chong P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Here we investigate the immunogenicity of a combination adjuvant comprising emulsified fine particles (namely PELC) together with LD-indolicidin, a peptiomimetic stereoisomer of the bovine neutrophil peptide indolicidin. We demonstrated that intranasal either PELC/LD-indolicidin or Alum enhances protective influenza-specific serological immunity in mice; however, the adjuvant potency of Alum was rather reduced when the mice vaccinated orally with formulated influenza vaccines. The information gathered from this study will enhance our effort in the formulation design as well as the optimization of alternative administration routes for prophylactic vaccines against emerging infectious diseases, in particular pandemic influenza.
Copyright ? 2016. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] Combination adjuvant; Host defense peptides; Mucosal vaccine; Vaccine delivery systems
PMID: 27394146 DOI: 10.1016/j.micinf.2016.06.007
[PubMed - as supplied by publisher]
[h=1]Mucosal delivery of a combination adjuvant comprising emulsified fine particles and LD-indolicidin enhances serological immunity to inactivated influenza virus.[/h] Huang MH[SUP]1[/SUP], Dai SH[SUP]2[/SUP], Chong P[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Here we investigate the immunogenicity of a combination adjuvant comprising emulsified fine particles (namely PELC) together with LD-indolicidin, a peptiomimetic stereoisomer of the bovine neutrophil peptide indolicidin. We demonstrated that intranasal either PELC/LD-indolicidin or Alum enhances protective influenza-specific serological immunity in mice; however, the adjuvant potency of Alum was rather reduced when the mice vaccinated orally with formulated influenza vaccines. The information gathered from this study will enhance our effort in the formulation design as well as the optimization of alternative administration routes for prophylactic vaccines against emerging infectious diseases, in particular pandemic influenza.
Copyright ? 2016. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] Combination adjuvant; Host defense peptides; Mucosal vaccine; Vaccine delivery systems
PMID: 27394146 DOI: 10.1016/j.micinf.2016.06.007
[PubMed - as supplied by publisher]