tetano
Editor, Senior Moderator
mSystems
. 2023 Dec 14:e0071323.
doi: 10.1128/msystems.00713-23. Online ahead of print. The most exposed regions of SARS-CoV-2 structural proteins are subject to strong positive selection and gene overlap may locally modify this behavior
Alejandro Rubio[SUP] 1 [/SUP], Maria de Toro[SUP] 2 [/SUP], Antonio J Pérez-Pulido[SUP] 1 [/SUP]
Affiliations
We have analyzed the selection pressure of all severe acute respiratory syndrome coronavirus 2 genes by means of the nonsynonymous (Ka) to synonymous (Ks) substitution rate. We found that protein-coding genes are exposed to strong positive selection, especially in the regions of interaction with other molecules (host receptor and genome of the virus itself). However, overlapping coding regions are more protected and show negative selection. This suggests that this measure could be used to study viral gene function as well as overlapping genes.
Keywords: Ka/Ks ratio; SARS-CoV-2; overlapping genes; selection pressure.
. 2023 Dec 14:e0071323.
doi: 10.1128/msystems.00713-23. Online ahead of print. The most exposed regions of SARS-CoV-2 structural proteins are subject to strong positive selection and gene overlap may locally modify this behavior
Alejandro Rubio[SUP] 1 [/SUP], Maria de Toro[SUP] 2 [/SUP], Antonio J Pérez-Pulido[SUP] 1 [/SUP]
Affiliations
- PMID: 38095866
- DOI: 10.1128/msystems.00713-23
We have analyzed the selection pressure of all severe acute respiratory syndrome coronavirus 2 genes by means of the nonsynonymous (Ka) to synonymous (Ks) substitution rate. We found that protein-coding genes are exposed to strong positive selection, especially in the regions of interaction with other molecules (host receptor and genome of the virus itself). However, overlapping coding regions are more protected and show negative selection. This suggests that this measure could be used to study viral gene function as well as overlapping genes.
Keywords: Ka/Ks ratio; SARS-CoV-2; overlapping genes; selection pressure.