tetano
Editor, Senior Moderator
mSphere
. 2022 May 19;e0017922.
doi: 10.1128/msphere.00179-22. Online ahead of print.
PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2
Viviana Simon[SUP] 1 2 3 4 5 [/SUP], Vamsi Kota[SUP] 6 [/SUP], Ryan F Bloomquist[SUP] 7 [/SUP], Hannah B Hanley[SUP] 8 [/SUP], David Forgacs[SUP] 8 [/SUP], Savita Pahwa[SUP] 9 [/SUP], Suresh Pallikkuth[SUP] 9 [/SUP], Loren G Miller[SUP] 10 11 [/SUP], Joanna Schaenman[SUP] 10 [/SUP], Michael R Yeaman[SUP] 10 11 [/SUP], David Manthei[SUP] 12 [/SUP], Joshua Wolf[SUP] 13 [/SUP], Aditya H Gaur[SUP] 13 [/SUP], Jeremie H Estepp[SUP] 13 [/SUP], Komal Srivastava[SUP] 1 [/SUP], Juan Manuel Carreño[SUP] 1 [/SUP], Frans Cuevas[SUP] 1 [/SUP], PARIS/SPARTA Study Group,; Ali H Ellebedy[SUP] 14 15 16 [/SUP], Aubree Gordon[SUP] 12 [/SUP], Riccardo Valdez[SUP] 17 [/SUP], Sarah Cobey[SUP] 18 [/SUP], Elaine F Reed[SUP] 19 [/SUP], Ravindra Kolhe[SUP] 20 6 7 [/SUP], Paul G Thomas[SUP] 13 [/SUP], Stacey Schultz-Cherry[SUP] 13 [/SUP], Ted M Ross[SUP] 8 21 [/SUP], Florian Krammer[SUP] 1 4 5 [/SUP]
Affiliations
Abstract
To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.
Keywords: COVID-19; SARS-CoV-2; antibodies; cohort study; reinfection.
. 2022 May 19;e0017922.
doi: 10.1128/msphere.00179-22. Online ahead of print.
PARIS and SPARTA: Finding the Achilles' Heel of SARS-CoV-2
Viviana Simon[SUP] 1 2 3 4 5 [/SUP], Vamsi Kota[SUP] 6 [/SUP], Ryan F Bloomquist[SUP] 7 [/SUP], Hannah B Hanley[SUP] 8 [/SUP], David Forgacs[SUP] 8 [/SUP], Savita Pahwa[SUP] 9 [/SUP], Suresh Pallikkuth[SUP] 9 [/SUP], Loren G Miller[SUP] 10 11 [/SUP], Joanna Schaenman[SUP] 10 [/SUP], Michael R Yeaman[SUP] 10 11 [/SUP], David Manthei[SUP] 12 [/SUP], Joshua Wolf[SUP] 13 [/SUP], Aditya H Gaur[SUP] 13 [/SUP], Jeremie H Estepp[SUP] 13 [/SUP], Komal Srivastava[SUP] 1 [/SUP], Juan Manuel Carreño[SUP] 1 [/SUP], Frans Cuevas[SUP] 1 [/SUP], PARIS/SPARTA Study Group,; Ali H Ellebedy[SUP] 14 15 16 [/SUP], Aubree Gordon[SUP] 12 [/SUP], Riccardo Valdez[SUP] 17 [/SUP], Sarah Cobey[SUP] 18 [/SUP], Elaine F Reed[SUP] 19 [/SUP], Ravindra Kolhe[SUP] 20 6 7 [/SUP], Paul G Thomas[SUP] 13 [/SUP], Stacey Schultz-Cherry[SUP] 13 [/SUP], Ted M Ross[SUP] 8 21 [/SUP], Florian Krammer[SUP] 1 4 5 [/SUP]
Affiliations
- PMID: 35586986
- DOI: 10.1128/msphere.00179-22
Abstract
To understand reinfection rates and correlates of protection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we established eight different longitudinal cohorts in 2020 under the umbrella of the PARIS (Protection Associated with Rapid Immunity to SARS-CoV-2)/SPARTA (SARS SeroPrevalence And Respiratory Tract Assessment) studies. Here, we describe the PARIS/SPARTA cohorts, the harmonized assays and analysis that are performed across the cohorts, as well as case definitions for SARS-CoV-2 infection and reinfection that have been established by the team of PARIS/SPARTA investigators. IMPORTANCE Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.
Keywords: COVID-19; SARS-CoV-2; antibodies; cohort study; reinfection.