tetano
Editor, Senior Moderator
J Infect Dis. 2018 Aug 28. doi: 10.1093/infdis/jiy517. [Epub ahead of print]
[h=1]Mortality in children in the community associated with acute respiratory infections.[/h] Caballero MT[SUP]1[/SUP], Bianchi AM[SUP]1[/SUP], Nu?o A[SUP]2[/SUP], Ferretti AJP[SUP]1[/SUP], Polack LM[SUP]1[/SUP], Remondino I[SUP]3[/SUP], Rodriguez MG[SUP]3[/SUP], Orizzonte L[SUP]2[/SUP], Vallone F[SUP]4[/SUP], Bergel E[SUP]5[/SUP], Polack FP[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Numerous deaths in children under five years (U5) of age in the developing world occur at home. Acute respiratory infections (ARI) are thought to play an important role in these deaths. Risk factors, and pathogens linked to fatal episodes remain unclear.
[h=4]Methods:[/h] A case-control study to define risk factors and viral pathogens in community death due to ARI in a low-income children U5 of Buenos Aires, Argentina.
[h=4]Results:[/h] 278 families of children U5 (104 deaths,174 healthy controls) participated in the study. Infants <12 months suffered 87.5% deaths. Death rate due to ARI was estimated at 5.02/1,000 live births in infants. Associations for dying at home due to ARI were observed for living in crowded homes (OR3.73,95%CI 1.41-9.88), having adolescent mothers (OR4.89,95%CI 1.37-17.38), no running water (OR4.39,95%CI 1.11-17.38), incomplete vaccinations (OR3.39,95%CI 1.20 - 9.62), neonatal intensive care admission (OR7.17,95%CI 2.21 - 23.27), and no visit to the ED (OR72.32,95%CI 4.82 - 1085.6). The infant community death rate due to RSV was 0.26 and due to influenza was 0.07/1000 live births.
[h=4]Conclusions:[/h] Social vulnerabilities underlie community mortality due to ARI. Home mortality rates for infants due to RSV and influenza are high, and similar to those reported for hospitalized children.
PMID: 30165655 DOI: 10.1093/infdis/jiy517
[h=1]Mortality in children in the community associated with acute respiratory infections.[/h] Caballero MT[SUP]1[/SUP], Bianchi AM[SUP]1[/SUP], Nu?o A[SUP]2[/SUP], Ferretti AJP[SUP]1[/SUP], Polack LM[SUP]1[/SUP], Remondino I[SUP]3[/SUP], Rodriguez MG[SUP]3[/SUP], Orizzonte L[SUP]2[/SUP], Vallone F[SUP]4[/SUP], Bergel E[SUP]5[/SUP], Polack FP[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Numerous deaths in children under five years (U5) of age in the developing world occur at home. Acute respiratory infections (ARI) are thought to play an important role in these deaths. Risk factors, and pathogens linked to fatal episodes remain unclear.
[h=4]Methods:[/h] A case-control study to define risk factors and viral pathogens in community death due to ARI in a low-income children U5 of Buenos Aires, Argentina.
[h=4]Results:[/h] 278 families of children U5 (104 deaths,174 healthy controls) participated in the study. Infants <12 months suffered 87.5% deaths. Death rate due to ARI was estimated at 5.02/1,000 live births in infants. Associations for dying at home due to ARI were observed for living in crowded homes (OR3.73,95%CI 1.41-9.88), having adolescent mothers (OR4.89,95%CI 1.37-17.38), no running water (OR4.39,95%CI 1.11-17.38), incomplete vaccinations (OR3.39,95%CI 1.20 - 9.62), neonatal intensive care admission (OR7.17,95%CI 2.21 - 23.27), and no visit to the ED (OR72.32,95%CI 4.82 - 1085.6). The infant community death rate due to RSV was 0.26 and due to influenza was 0.07/1000 live births.
[h=4]Conclusions:[/h] Social vulnerabilities underlie community mortality due to ARI. Home mortality rates for infants due to RSV and influenza are high, and similar to those reported for hospitalized children.
PMID: 30165655 DOI: 10.1093/infdis/jiy517