Morphofunctional Characteristics of Fibroblasts and Fibrogenesis in the Lungs of Mice Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Vi

[tetano]

Bull Exp Biol Med. 2012 Dec;154(3):361-4.
Morphofunctional Characteristics of Fibroblasts and Fibrogenesis in the Lungs of Mice Infected with Influenza A/H5N1 A/Goose/Krasnoozerskoye/627/05 Virus.
[Article in English, Russian]
Anikina AG, Potapova OV, Shkurupy VA.
Source

Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. potapova@soramn.ru.
Abstract

Mice C57Bl/6 were intranasally infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The expression of influenza A virus antigen in the lung interstitium fibroblasts was recorded during all periods of the study (on days 1-14 after infection), the maximum expression on days 1 and 3. On day 1, the volume density of collagen fibers in the lungs was 3-fold higher than in intact animals; by day 14 it increased almost 15-fold. The numerical density of PCNAfibroblasts increased almost 2-fold from day 1 to day 10; "fibroplastic activity" of fibroblasts increased more than 3-fold.

PMID:
23484201
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23484201