tetano
Editor, Senior Moderator
J Clin Virol. 2019 Apr 7;116:11-17. doi: 10.1016/j.jcv.2019.04.003. [Epub ahead of print]
[h=1]More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.[/h] Vos LM[SUP]1[/SUP], Weehuizen JM[SUP]2[/SUP], Hoepelman AIM[SUP]2[/SUP], Kaasjager KHAH[SUP]3[/SUP], Riezebos-Brilman A[SUP]4[/SUP], Oosterheert JJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).
[h=4]OBJECTIVES:[/h] Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.
[h=4]STUDY DESIGN:[/h] A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. During the first season (2016/2017), respiratory viruses were detected using inhouse real-time PCR. The second season (2017/2018), we implemented a diagnostic flowchart including a rapid molecular test for 15 respiratory viruses (FilmArray?). We assessed the effect of this implementation on need for isolation, antivirals and empirical antibiotics.
[h=4]RESULTS:[/h] We included 192 immunocompromised adult patients during the first and 378 during the second season. Respiratory viral testing was performed in 135 patients (70%) during the first and 284 (75%) during the second season (p = 0.218) of which 213 (75%) using the rapid test. After implementation, use of in-hospital isolation facilities was reduced (adjusted odds ratio 0.35, 95%CI 0.19-0.64). Furthermore, adequate use of oseltamivir improved, with fewer prescriptions in influenza negative patients (0.15, 95%CI 0.08-0.28) and more in influenza positive patients (11.13, 95%CI 1.75-70.86). No effect was observed on empirical antibiotic use, hospital admissions, length of hospital stay or safety outcomes.
[h=4]CONCLUSIONS:[/h] Implementation of rapid molecular testing for respiratory viruses in adult immunocompromised patients results in more adequate use of oseltamivir and in-hospital isolation facilities without compromising safety.
Copyright ? 2019 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Clinical impact; Immunocompromised; Rapid molecular diagnostics; Respiratory viruses
PMID: 30999234 DOI: 10.1016/j.jcv.2019.04.003
[h=1]More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.[/h] Vos LM[SUP]1[/SUP], Weehuizen JM[SUP]2[/SUP], Hoepelman AIM[SUP]2[/SUP], Kaasjager KHAH[SUP]3[/SUP], Riezebos-Brilman A[SUP]4[/SUP], Oosterheert JJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).
[h=4]OBJECTIVES:[/h] Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.
[h=4]STUDY DESIGN:[/h] A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. During the first season (2016/2017), respiratory viruses were detected using inhouse real-time PCR. The second season (2017/2018), we implemented a diagnostic flowchart including a rapid molecular test for 15 respiratory viruses (FilmArray?). We assessed the effect of this implementation on need for isolation, antivirals and empirical antibiotics.
[h=4]RESULTS:[/h] We included 192 immunocompromised adult patients during the first and 378 during the second season. Respiratory viral testing was performed in 135 patients (70%) during the first and 284 (75%) during the second season (p = 0.218) of which 213 (75%) using the rapid test. After implementation, use of in-hospital isolation facilities was reduced (adjusted odds ratio 0.35, 95%CI 0.19-0.64). Furthermore, adequate use of oseltamivir improved, with fewer prescriptions in influenza negative patients (0.15, 95%CI 0.08-0.28) and more in influenza positive patients (11.13, 95%CI 1.75-70.86). No effect was observed on empirical antibiotic use, hospital admissions, length of hospital stay or safety outcomes.
[h=4]CONCLUSIONS:[/h] Implementation of rapid molecular testing for respiratory viruses in adult immunocompromised patients results in more adequate use of oseltamivir and in-hospital isolation facilities without compromising safety.
Copyright ? 2019 Elsevier B.V. All rights reserved.
[h=4]KEYWORDS:[/h] Clinical impact; Immunocompromised; Rapid molecular diagnostics; Respiratory viruses
PMID: 30999234 DOI: 10.1016/j.jcv.2019.04.003