tetano
Editor, Senior Moderator
Monaldi Arch Chest Dis
. 2022 Jun 24.
doi: 10.4081/monaldi.2022.2281. Online ahead of print.
Tuberculosis endemicity and BCG vaccination: Protection against COVID-19
Tarun Krishna Boppana[SUP] 1 [/SUP], Saurabh Mittal[SUP] 2 [/SUP], Karan Madan[SUP] 3 [/SUP], Anant Mohan[SUP] 4 [/SUP], Vijay Hadda[SUP] 5 [/SUP], Randeep Guleria[SUP] 6 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) has affected different countries in a differential manner. The host susceptibility and host factors are important parameters for this variability. This study aimed to assess the effect of tuberculosis (TB) endemicity and Bacille Calmette-Guerin (BCG) coverage on COVID-19. Available data regarding TB incidence, BCG coverage (as per the World Health Organization), and COVID-19 incidence of 168 countries as of 19th September 2021. Countries were divided into four cohorts based upon annual TB incidence and BCG coverage and COVID-19 incidence and case fatality rates were compared using the Kruskal-Wallis test. Countries with low TB incidence and low BCG coverage had the highest COVID-19 incidence per lac population. However, no significant difference was seen in COVID-19 cases fatality rate. Higher TB incidence and BCG coverage were associated with lesser incidence of COVID-19. This result paves the way for research into pathogenesis and host immune response in COVID-19.
. 2022 Jun 24.
doi: 10.4081/monaldi.2022.2281. Online ahead of print.
Tuberculosis endemicity and BCG vaccination: Protection against COVID-19
Tarun Krishna Boppana[SUP] 1 [/SUP], Saurabh Mittal[SUP] 2 [/SUP], Karan Madan[SUP] 3 [/SUP], Anant Mohan[SUP] 4 [/SUP], Vijay Hadda[SUP] 5 [/SUP], Randeep Guleria[SUP] 6 [/SUP]
Affiliations
- PMID: 35754393
- DOI: 10.4081/monaldi.2022.2281
Abstract
The coronavirus disease 2019 (COVID-19) has affected different countries in a differential manner. The host susceptibility and host factors are important parameters for this variability. This study aimed to assess the effect of tuberculosis (TB) endemicity and Bacille Calmette-Guerin (BCG) coverage on COVID-19. Available data regarding TB incidence, BCG coverage (as per the World Health Organization), and COVID-19 incidence of 168 countries as of 19th September 2021. Countries were divided into four cohorts based upon annual TB incidence and BCG coverage and COVID-19 incidence and case fatality rates were compared using the Kruskal-Wallis test. Countries with low TB incidence and low BCG coverage had the highest COVID-19 incidence per lac population. However, no significant difference was seen in COVID-19 cases fatality rate. Higher TB incidence and BCG coverage were associated with lesser incidence of COVID-19. This result paves the way for research into pathogenesis and host immune response in COVID-19.