tetano
Editor, Senior Moderator
PLoS One. 2014 Jul 30;9(7):e102453. doi: 10.1371/journal.pone.0102453. eCollection 2014.
Molecular Epidemiology of Influenza A/H3N2 Viruses Circulating in Mexico from 2003 to 2012.
Escalera-Zamudio M1, Nelson MI2, Cobi?n G?emes AG1, L?pez-Mart?nez I3, Cruz-Ortiz N3, Iguala-Vidales M3, Garc?a ER3, Barrera-Badillo G3, D?az-Qui?onez JA3, L?pez S1, Arias CF1, Isa P1; Members of Colegio de Pediatr?a del Estado de Veracruz.
Author information
Abstract
In this work, nineteen influenza A/H3N2 viruses isolated in Mexico between 2003 and 2012 were studied. Our findings show that different human A/H3N2 viral lineages co-circulate within a same season and can also persist locally in between different influenza seasons, increasing the chance for genetic reassortment events. A novel minor cluster was also identified, named here as Korea, that circulated worldwide during 2003. Frequently, phylogenetic characterization did not correlate with the determined antigenic identity, supporting the need for the use of molecular evolutionary tools additionally to antigenic data for the surveillance and characterization of viral diversity during each flu season. This work represents the first long-term molecular epidemiology study of influenza A/H3N2 viruses in Mexico based on the complete genomic sequences and contributes to the monitoring of evolutionary trends of A/H3N2 influenza viruses within North and Central America.
PMID:
25075517
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25075517
Molecular Epidemiology of Influenza A/H3N2 Viruses Circulating in Mexico from 2003 to 2012.
Escalera-Zamudio M1, Nelson MI2, Cobi?n G?emes AG1, L?pez-Mart?nez I3, Cruz-Ortiz N3, Iguala-Vidales M3, Garc?a ER3, Barrera-Badillo G3, D?az-Qui?onez JA3, L?pez S1, Arias CF1, Isa P1; Members of Colegio de Pediatr?a del Estado de Veracruz.
Author information
Abstract
In this work, nineteen influenza A/H3N2 viruses isolated in Mexico between 2003 and 2012 were studied. Our findings show that different human A/H3N2 viral lineages co-circulate within a same season and can also persist locally in between different influenza seasons, increasing the chance for genetic reassortment events. A novel minor cluster was also identified, named here as Korea, that circulated worldwide during 2003. Frequently, phylogenetic characterization did not correlate with the determined antigenic identity, supporting the need for the use of molecular evolutionary tools additionally to antigenic data for the surveillance and characterization of viral diversity during each flu season. This work represents the first long-term molecular epidemiology study of influenza A/H3N2 viruses in Mexico based on the complete genomic sequences and contributes to the monitoring of evolutionary trends of A/H3N2 influenza viruses within North and Central America.
PMID:
25075517
[PubMed - in process]
Free full text
http://www.ncbi.nlm.nih.gov/pubmed/25075517