tetano
Editor, Senior Moderator
Rev Inst Med Trop Sao Paulo. 2017 Apr 3;59:e9. doi: 10.1590/S1678-9946201759009.
[h=1]Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in S?o Paulo State , Brazil: 2016 anticipated influenza season.[/h] Santos KC[SUP]1[/SUP], Silva DB[SUP]1[/SUP], Sasaki NA[SUP]1[/SUP], Benega MA[SUP]1[/SUP], Garten R[SUP]2[/SUP], Paiva TM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Compared to previous years, seasonal influenza activity commenced early in S?o Paulo State, Brazil, Southern hemisphere during the 2016 year. In order to investigate the genetic pattern of influenza A(H1N1)pdm09 in the State of Sao Paulo a total of 479 respiratory samples, collected in January by Sentinel Surveillance Units, were screened by real-time RT-PCR. A total of 6 Influenza viruses A(H1N1)pdm09 presenting ct values ≤ 30 were sequenced following phylogenetic analysis. The present study identified the circulation of the new 6B.1 subgroup (A/Sao Paulo/10-118/2016 and A/Sao Paulo/3032/2016). In addition, influenza A(H1N1)pdm09 group 6B has also been identified during January in the State of Sao Paulo. Despite amino acid changes and changes in potential glycosylation motifs, 6B.1 viruses were well inhibited by the reference ferret antiserum against A/California/07/2009 virus, the A(H1N1)pdm09 component of the vaccine for the 2016 influenza season.
PMID: 28380120 DOI: 10.1590/S1678-9946201759009
[h=1]Molecular epidemiology of influenza A(H1N1)PDM09 hemagglutinin gene circulating in S?o Paulo State , Brazil: 2016 anticipated influenza season.[/h] Santos KC[SUP]1[/SUP], Silva DB[SUP]1[/SUP], Sasaki NA[SUP]1[/SUP], Benega MA[SUP]1[/SUP], Garten R[SUP]2[/SUP], Paiva TM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Compared to previous years, seasonal influenza activity commenced early in S?o Paulo State, Brazil, Southern hemisphere during the 2016 year. In order to investigate the genetic pattern of influenza A(H1N1)pdm09 in the State of Sao Paulo a total of 479 respiratory samples, collected in January by Sentinel Surveillance Units, were screened by real-time RT-PCR. A total of 6 Influenza viruses A(H1N1)pdm09 presenting ct values ≤ 30 were sequenced following phylogenetic analysis. The present study identified the circulation of the new 6B.1 subgroup (A/Sao Paulo/10-118/2016 and A/Sao Paulo/3032/2016). In addition, influenza A(H1N1)pdm09 group 6B has also been identified during January in the State of Sao Paulo. Despite amino acid changes and changes in potential glycosylation motifs, 6B.1 viruses were well inhibited by the reference ferret antiserum against A/California/07/2009 virus, the A(H1N1)pdm09 component of the vaccine for the 2016 influenza season.
PMID: 28380120 DOI: 10.1590/S1678-9946201759009