tetano
Editor, Senior Moderator
Infect Genet Evol. 2019 Jul 17:103969. doi: 10.1016/j.meegid.2019.103969. [Epub ahead of print]
[h=1]Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016-2018.[/h] AlIbrahim M[SUP]1[/SUP], Assaf-Casals A[SUP]2[/SUP], Massaad E[SUP]3[/SUP], Shaker R[SUP]2[/SUP], Soudani N[SUP]1[/SUP], Fayad D[SUP]2[/SUP], Chamseddine S[SUP]2[/SUP], Lteif-Khoury M[SUP]2[/SUP], Chmaisse A[SUP]2[/SUP], Isaac I[SUP]2[/SUP], Anan H[SUP]2[/SUP], Sadaka C[SUP]2[/SUP], Radwan N[SUP]2[/SUP], Ghanem S[SUP]4[/SUP], Naous A[SUP]4[/SUP], Karam M[SUP]5[/SUP], Andary R[SUP]6[/SUP], Dbaibo G[SUP]2[/SUP], Zaraket H[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza B viruses are a major cause of serious acute respiratory infections in humans.
[h=4]METHODS:[/h] Nasopharyngeal swabs were collected from subjects with influenza-like illness during October 2016-June 2018 and screened for influenza A and B. The hemagglutinin (HA) and neuraminidase (NA) genes of the Lebanese influenza B specimens were sequenced and phylogenetically compared with the vaccine strains and specimens from the Eastern Mediterranean Region and Europe.
[h=4]RESULTS:[/h] Influenza A and B viruses co-circulated between October and May and peaked between January and March. During the 2016-2017 season, A/H3N2 (33.4%) and B/Yamagata (29.7%) were the predominantly circulating viruses followed by B/Victoria and A/H1N1pdm09 viruses. During the 2017-2018 season, A/H3N2 (31.5%) and A/H1Npdm09 (29.3%) were most prevalent with co-circulation of B/Yamagata and to a lesser extent B/Victoria viruses. The B/Yamagata specimens belonged to clade-3 while the B/Victoria belonged to clade-1A. None of the analyzed specimens had a mutation known to confer resistance to NA inhibitors (NAIs).
[h=4]CONCLUSION:[/h] Multiple subtypes of influenza co-circulate each year in Lebanon with a peak between January and March. The trivalent vaccine included a B/Victoria strain which mismatched the B/Yamagata lineage that predominated during the study period, highlighting the importance of quadrivalent vaccines.
Copyright ? 2018. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Influenza; Lebanon; Phylogenetic analysis; Surveillance; Vaccination
PMID: 31325610 DOI: 10.1016/j.meegid.2019.103969
[h=1]Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016-2018.[/h] AlIbrahim M[SUP]1[/SUP], Assaf-Casals A[SUP]2[/SUP], Massaad E[SUP]3[/SUP], Shaker R[SUP]2[/SUP], Soudani N[SUP]1[/SUP], Fayad D[SUP]2[/SUP], Chamseddine S[SUP]2[/SUP], Lteif-Khoury M[SUP]2[/SUP], Chmaisse A[SUP]2[/SUP], Isaac I[SUP]2[/SUP], Anan H[SUP]2[/SUP], Sadaka C[SUP]2[/SUP], Radwan N[SUP]2[/SUP], Ghanem S[SUP]4[/SUP], Naous A[SUP]4[/SUP], Karam M[SUP]5[/SUP], Andary R[SUP]6[/SUP], Dbaibo G[SUP]2[/SUP], Zaraket H[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza B viruses are a major cause of serious acute respiratory infections in humans.
[h=4]METHODS:[/h] Nasopharyngeal swabs were collected from subjects with influenza-like illness during October 2016-June 2018 and screened for influenza A and B. The hemagglutinin (HA) and neuraminidase (NA) genes of the Lebanese influenza B specimens were sequenced and phylogenetically compared with the vaccine strains and specimens from the Eastern Mediterranean Region and Europe.
[h=4]RESULTS:[/h] Influenza A and B viruses co-circulated between October and May and peaked between January and March. During the 2016-2017 season, A/H3N2 (33.4%) and B/Yamagata (29.7%) were the predominantly circulating viruses followed by B/Victoria and A/H1N1pdm09 viruses. During the 2017-2018 season, A/H3N2 (31.5%) and A/H1Npdm09 (29.3%) were most prevalent with co-circulation of B/Yamagata and to a lesser extent B/Victoria viruses. The B/Yamagata specimens belonged to clade-3 while the B/Victoria belonged to clade-1A. None of the analyzed specimens had a mutation known to confer resistance to NA inhibitors (NAIs).
[h=4]CONCLUSION:[/h] Multiple subtypes of influenza co-circulate each year in Lebanon with a peak between January and March. The trivalent vaccine included a B/Victoria strain which mismatched the B/Yamagata lineage that predominated during the study period, highlighting the importance of quadrivalent vaccines.
Copyright ? 2018. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Influenza; Lebanon; Phylogenetic analysis; Surveillance; Vaccination
PMID: 31325610 DOI: 10.1016/j.meegid.2019.103969