tetano
Editor, Senior Moderator
J Gen Virol. 2014 Apr 10. doi: 10.1099/vir.0.063495-0. [Epub ahead of print]
Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic sub-clade.
El-Shesheny R1, Kandeil A, Bagato O, Maatouq AM, Moatasim Y, Rubrum A, Song MS, Webby RJ, Ali MA, Kayali G.
Author information
Abstract
CClade 2.2 highly pathogenic H5N1 viruses have been in continuous circulation in Egyptian poultry since 2006. Their persistence caused significant genetic drift that led to the re-classification of these viruses into sub-clades 2.2.1 and 2.2.1.1. Here, we conducted full genome sequence and phylogenetic analyses of 45 H5N1 isolated during 2006-2013 through systematic surveillance in Egypt, and 53 viruses that were previously sequenced and available in the public domain. Results indicate that H5N1 viruses in Egypt continue to evolve and a new distinct cluster has emerged. Mutations affecting viral virulence, pathogenicity, transmission, receptor-binding preference, and drug resistance were studied. In light of our findings that H5N1 in Egypt continues to evolve, surveillance and molecular studies need to be sustained.
KEYWORDS:
Avian Influenza, Egypt, H5N1, Molecular analysis
PMID:
24722680
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24722680
Molecular characterization of avian influenza H5N1 virus in Egypt and the emergence of a novel endemic sub-clade.
El-Shesheny R1, Kandeil A, Bagato O, Maatouq AM, Moatasim Y, Rubrum A, Song MS, Webby RJ, Ali MA, Kayali G.
Author information
Abstract
CClade 2.2 highly pathogenic H5N1 viruses have been in continuous circulation in Egyptian poultry since 2006. Their persistence caused significant genetic drift that led to the re-classification of these viruses into sub-clades 2.2.1 and 2.2.1.1. Here, we conducted full genome sequence and phylogenetic analyses of 45 H5N1 isolated during 2006-2013 through systematic surveillance in Egypt, and 53 viruses that were previously sequenced and available in the public domain. Results indicate that H5N1 viruses in Egypt continue to evolve and a new distinct cluster has emerged. Mutations affecting viral virulence, pathogenicity, transmission, receptor-binding preference, and drug resistance were studied. In light of our findings that H5N1 in Egypt continues to evolve, surveillance and molecular studies need to be sustained.
KEYWORDS:
Avian Influenza, Egypt, H5N1, Molecular analysis
PMID:
24722680
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24722680