tetano
Editor, Senior Moderator
Methods Mol Biol. 2014;1200:447-80. doi: 10.1007/978-1-4939-1292-6_38.
Molecular basis of a pandemic of avian-type influenza virus.
Sriwilaijaroen N1, Suzuki Y.
Author information
Abstract
Despite heroic efforts to prevent the emergence of an influenza pandemic, avian influenza A virus has prevailed by crossing the species barriers to infect humans worldwide, occasionally with morbidity and mortality at unprecedented levels, and the virus later usually continues circulation in humans as a seasonal influenza virus, resulting in health-social-economic problems each year. Here, we review current knowledge of influenza viruses, their life cycle, interspecies transmission, and past pandemics and discuss the molecular basis of pandemic acquisition, notably of hemagglutinin (lectin) acting as a key contributor to change in host specificity in viral infection.
PMID:
25117257
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25117257
Molecular basis of a pandemic of avian-type influenza virus.
Sriwilaijaroen N1, Suzuki Y.
Author information
Abstract
Despite heroic efforts to prevent the emergence of an influenza pandemic, avian influenza A virus has prevailed by crossing the species barriers to infect humans worldwide, occasionally with morbidity and mortality at unprecedented levels, and the virus later usually continues circulation in humans as a seasonal influenza virus, resulting in health-social-economic problems each year. Here, we review current knowledge of influenza viruses, their life cycle, interspecies transmission, and past pandemics and discuss the molecular basis of pandemic acquisition, notably of hemagglutinin (lectin) acting as a key contributor to change in host specificity in viral infection.
PMID:
25117257
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25117257