tetano
Editor, Senior Moderator
Mol Med
. 2021 Dec 27;27(1):162.
doi: 10.1186/s10020-021-00423-y.
Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
Svetlana P Chapoval[SUP] 1 2 3 4 [/SUP], Achsah D Keegan[SUP] 5 6 7 8 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike-NRP1 interaction to combat virus infectivity and severe disease manifestations.
Keywords: ACE2, angiotensin converting enzyme 2; COVID-19, coronavirus disease 2019; CendR C-end rule; Comorbidities; Host immune response; Immunotargets and strategies; Molecular structures; NRP-1, neuropilin-1; RBD, receptor-biding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; Spike protein.
. 2021 Dec 27;27(1):162.
doi: 10.1186/s10020-021-00423-y.
Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
Svetlana P Chapoval[SUP] 1 2 3 4 [/SUP], Achsah D Keegan[SUP] 5 6 7 8 [/SUP]
Affiliations
- PMID: 34961486
- DOI: 10.1186/s10020-021-00423-y
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike-NRP1 interaction to combat virus infectivity and severe disease manifestations.
Keywords: ACE2, angiotensin converting enzyme 2; COVID-19, coronavirus disease 2019; CendR C-end rule; Comorbidities; Host immune response; Immunotargets and strategies; Molecular structures; NRP-1, neuropilin-1; RBD, receptor-biding domain; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; Spike protein.