tetano
Editor, Senior Moderator
Mol Cells
. 2021 Jun 1.
doi: 10.14348/molcells.2021.0075. Online ahead of print.
Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis
Eunjin Lee[SUP] 1 [/SUP], Ji Eun Oh[SUP] 1 2 [/SUP]
Affiliations
Abstract
It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV-2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARSCoV-2 variants, and highlight gaps in the current knowledge.
Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 variants; humoral immunity; neutralizing antibody.
. 2021 Jun 1.
doi: 10.14348/molcells.2021.0075. Online ahead of print.
Humoral Immunity against SARS-CoV-2 and the Impact on COVID-19 Pathogenesis
Eunjin Lee[SUP] 1 [/SUP], Ji Eun Oh[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34059562
- DOI: 10.14348/molcells.2021.0075
Abstract
It has been more than a year since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged. Many studies have provided insights into the various aspects of the immune response in coronavirus disease 2019 (COVID-19). Especially for antibody treatment and vaccine development, humoral immunity to SARS-CoV-2 has been studied extensively, though there is still much that is unknown and controversial. Here, we introduce key discoveries on the humoral immune responses in COVID-19, including the immune dynamics of antibody responses and correlations with disease severity, neutralizing antibodies and their cross-reactivity, how long the antibody and memory B-cell responses last, aberrant autoreactive antibodies generated in COVID-19 patients, and the efficacy of currently available therapeutic antibodies and vaccines against circulating SARSCoV-2 variants, and highlight gaps in the current knowledge.
Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 variants; humoral immunity; neutralizing antibody.