tetano
Editor, Senior Moderator
Mol Cell Probes
. 2020 Jul 4;101636.
doi: 10.1016/j.mcp.2020.101636. Online ahead of print.
Aptamers, the Bivalent Agents as Probes and Therapies for Coronavirus Infections: A Systematic Review
Raheleh Torabi[SUP] 1 [/SUP], Reza Ranjbar[SUP] 2 [/SUP], Mehrdad Halaji[SUP] 3 [/SUP], Mohammad Heiat[SUP] 4 [/SUP]
Affiliations
Abstract
The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
Keywords: Aptamer; COVID-19; Coronavirus; MERS; Probe; SARS; SARS-CoV-2; Therapy.
. 2020 Jul 4;101636.
doi: 10.1016/j.mcp.2020.101636. Online ahead of print.
Aptamers, the Bivalent Agents as Probes and Therapies for Coronavirus Infections: A Systematic Review
Raheleh Torabi[SUP] 1 [/SUP], Reza Ranjbar[SUP] 2 [/SUP], Mehrdad Halaji[SUP] 3 [/SUP], Mohammad Heiat[SUP] 4 [/SUP]
Affiliations
- PMID: 32634550
- DOI: 10.1016/j.mcp.2020.101636
Abstract
The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made the situation more complicated. Efforts have led to production of several diagnostic kits that are associated with limitations such as inadequate sensitivity and accuracy. Aptamers as multipotent biological probes could be promising candidates to design sensitive and specific biosensors. Although few studies have introduced specific aptamer types of coronavirus, they may help us select the best approach to obtain specific aptamers for this virus. On the other hand, some of already-introduced aptamers have shown the inhibitory effects on coronavirus that could be applied as therapeutics. The present study has provided a systematic overview on use of aptamer-based biosensors and drugs to diagnose and treat coronavirus.
Keywords: Aptamer; COVID-19; Coronavirus; MERS; Probe; SARS; SARS-CoV-2; Therapy.