tetano
Editor, Senior Moderator
Mol Biomed
. 2021 Jan 20;2(1):1.
doi: 10.1186/s43556-020-00015-y.
Immunological perspectives on the pathogenesis, diagnosis, prevention and treatment of COVID-19
Yanghong Ni[SUP] #[/SUP][SUP] 1 2 [/SUP], Aqu Alu[SUP] #[/SUP][SUP] 1 [/SUP], Hong Lei[SUP] 1 [/SUP], Yang Wang[SUP] 1 [/SUP], Min Wu[SUP] 3 [/SUP], Xiawei Wei[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 can spread to the entire body and cause multiple organ failure. It is a daunting challenge to control the fast growing worldwide pandemic because effective prevention and treatment strategies are unavailable currently. Generally, the immune response of the human body triggered by viral infection is essential for the elimination of the virus. However, severe COVID-19 patients may manifest dysregulated immune responses, such as lymphopenia, lymphocyte exhaustion, exacerbated antibody response, cytokine release syndrome (CRS), etc. Understanding of these immunological characteristics may help identify better approaches for diagnosis, prognosis and treatment of COVID-19 patients. As specific anti-viral agents are notoriously difficult to develop, strategies for modulating the immune responses by either developing novel vaccines or using immunotherapy hold great promise to improve the management of SARS-CoV-2 infection.
Keywords: COVID-19; Diagnosis; Immunity; Immunotherapy; Pathogenesis; Vaccine.
. 2021 Jan 20;2(1):1.
doi: 10.1186/s43556-020-00015-y.
Immunological perspectives on the pathogenesis, diagnosis, prevention and treatment of COVID-19
Yanghong Ni[SUP] #[/SUP][SUP] 1 2 [/SUP], Aqu Alu[SUP] #[/SUP][SUP] 1 [/SUP], Hong Lei[SUP] 1 [/SUP], Yang Wang[SUP] 1 [/SUP], Min Wu[SUP] 3 [/SUP], Xiawei Wei[SUP] 4 [/SUP]
Affiliations
- PMID: 35006419
- DOI: 10.1186/s43556-020-00015-y
Abstract
Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). COVID-19 can spread to the entire body and cause multiple organ failure. It is a daunting challenge to control the fast growing worldwide pandemic because effective prevention and treatment strategies are unavailable currently. Generally, the immune response of the human body triggered by viral infection is essential for the elimination of the virus. However, severe COVID-19 patients may manifest dysregulated immune responses, such as lymphopenia, lymphocyte exhaustion, exacerbated antibody response, cytokine release syndrome (CRS), etc. Understanding of these immunological characteristics may help identify better approaches for diagnosis, prognosis and treatment of COVID-19 patients. As specific anti-viral agents are notoriously difficult to develop, strategies for modulating the immune responses by either developing novel vaccines or using immunotherapy hold great promise to improve the management of SARS-CoV-2 infection.
Keywords: COVID-19; Diagnosis; Immunity; Immunotherapy; Pathogenesis; Vaccine.