tetano
Editor, Senior Moderator
J Theor Biol. 2014 Mar 1. pii: S0022-5193(14)00104-0. doi: 10.1016/j.jtbi.2014.02.029. [Epub ahead of print]
Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.
Fribourg M1, Hartmann B1, Schmolke M2, Marjanovic N1, Albrecht RA2, Garc?a-Sastre A3, Sealfon SC1, Jayaprakash C4, Hayot F5.
Author information
Abstract
Viral antagonism of host responses is an essential component of virus pathogenicity. The study of the interplay between immune response and viral antagonism is challenging due to the involvement of many processes acting at multiple time scales. Here we develop an ordinary differential equation model to investigate the early, experimentally-measured, responses of human monocyte-derived dendritic cells to infection by two H1N1 influenza A viruses of different clinical outcome: pandemic A/California/4/2009 and seasonal A/New Caledonia/20/1999. Our results reveal how the strength of virus antagonism, and the time scale over which it acts to thwart the innate immune response, differ significantly between the two viruses, as is made clear by their impact on the temporal behavior of a number of measured genes. The model thus sheds light on the mechanisms that underlie the variability of innate immune responses to different H1N1 viruses.
Copyright ? 2014. Published by Elsevier Ltd.
PMID:
24594370
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24594370
Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.
Fribourg M1, Hartmann B1, Schmolke M2, Marjanovic N1, Albrecht RA2, Garc?a-Sastre A3, Sealfon SC1, Jayaprakash C4, Hayot F5.
Author information
Abstract
Viral antagonism of host responses is an essential component of virus pathogenicity. The study of the interplay between immune response and viral antagonism is challenging due to the involvement of many processes acting at multiple time scales. Here we develop an ordinary differential equation model to investigate the early, experimentally-measured, responses of human monocyte-derived dendritic cells to infection by two H1N1 influenza A viruses of different clinical outcome: pandemic A/California/4/2009 and seasonal A/New Caledonia/20/1999. Our results reveal how the strength of virus antagonism, and the time scale over which it acts to thwart the innate immune response, differ significantly between the two viruses, as is made clear by their impact on the temporal behavior of a number of measured genes. The model thus sheds light on the mechanisms that underlie the variability of innate immune responses to different H1N1 viruses.
Copyright ? 2014. Published by Elsevier Ltd.
PMID:
24594370
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24594370