tetano
Editor, Senior Moderator
Mod Pathol
. 2020 Aug 13.
doi: 10.1038/s41379-020-00649-x. Online ahead of print.
Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data
Stephen M Lagana[SUP] 1 [/SUP], Satoru Kudose[SUP] 2 [/SUP], Alina C Iuga[SUP] 2 [/SUP], Michael J Lee[SUP] 2 [/SUP], Ladan Fazlollahi[SUP] 2 [/SUP], Helen E Remotti[SUP] 2 [/SUP], Armando Del Portillo[SUP] 2 [/SUP], Simona De Michele[SUP] 2 [/SUP], Anne Koehne de Gonzalez[SUP] 2 [/SUP], Anjali Saqi[SUP] 2 [/SUP], Pascale Khairallah[SUP] 3 [/SUP], Alexander M Chong[SUP] 4 [/SUP], Heekuk Park[SUP] 4 [/SUP], Anne-Catrin Uhlemann[SUP] 4 [/SUP], Jay H Lefkowitch[SUP] 2 [/SUP], Elizabeth C Verna[SUP] 5 [/SUP]
Affiliations
Abstract
The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic pattern of injury has not been completely described. Studies quantifying viral load in the liver are lacking. Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. A subset of liver tissue blocks were subjected to polymerase chain reaction (PCR) for viral ribonucleic acid (RNA). Peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated; median ALT peak 68 U/l (normal up to 46 U/l) and median AST peak 102 U/l (normal up to 37 U/l). Macrovesicular steatosis was the most common finding, involving 30 patients (75%). Mild lobular necroinflammation and portal inflammation were present in 20 cases each (50%). Vascular pathology, including sinusoidal microthrombi, was infrequent, seen in six cases (15%). PCR of liver tissue was positive in 11 of 20 patients tested (55%). In conclusion, we found patients dying of COVID-19 had biochemical evidence of hepatitis (of variable severity) and demonstrated histologic findings of macrovesicular steatosis and mild acute hepatitis (lobular necroinflammation) and mild portal inflammation. We also identified viral RNA in a sizeable subset of liver tissue samples.
. 2020 Aug 13.
doi: 10.1038/s41379-020-00649-x. Online ahead of print.
Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data
Stephen M Lagana[SUP] 1 [/SUP], Satoru Kudose[SUP] 2 [/SUP], Alina C Iuga[SUP] 2 [/SUP], Michael J Lee[SUP] 2 [/SUP], Ladan Fazlollahi[SUP] 2 [/SUP], Helen E Remotti[SUP] 2 [/SUP], Armando Del Portillo[SUP] 2 [/SUP], Simona De Michele[SUP] 2 [/SUP], Anne Koehne de Gonzalez[SUP] 2 [/SUP], Anjali Saqi[SUP] 2 [/SUP], Pascale Khairallah[SUP] 3 [/SUP], Alexander M Chong[SUP] 4 [/SUP], Heekuk Park[SUP] 4 [/SUP], Anne-Catrin Uhlemann[SUP] 4 [/SUP], Jay H Lefkowitch[SUP] 2 [/SUP], Elizabeth C Verna[SUP] 5 [/SUP]
Affiliations
- PMID: 32792598
- DOI: 10.1038/s41379-020-00649-x
Abstract
The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic pattern of injury has not been completely described. Studies quantifying viral load in the liver are lacking. Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. A subset of liver tissue blocks were subjected to polymerase chain reaction (PCR) for viral ribonucleic acid (RNA). Peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated; median ALT peak 68 U/l (normal up to 46 U/l) and median AST peak 102 U/l (normal up to 37 U/l). Macrovesicular steatosis was the most common finding, involving 30 patients (75%). Mild lobular necroinflammation and portal inflammation were present in 20 cases each (50%). Vascular pathology, including sinusoidal microthrombi, was infrequent, seen in six cases (15%). PCR of liver tissue was positive in 11 of 20 patients tested (55%). In conclusion, we found patients dying of COVID-19 had biochemical evidence of hepatitis (of variable severity) and demonstrated histologic findings of macrovesicular steatosis and mild acute hepatitis (lobular necroinflammation) and mild portal inflammation. We also identified viral RNA in a sizeable subset of liver tissue samples.