tetano
Editor, Senior Moderator
J Virol. 2015 Oct 7. pii: JVI.01671-15. [Epub ahead of print]
[h=1]Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation.[/h] Anchisi S[SUP]1[/SUP], Guerra J[SUP]1[/SUP], Mottet-Osman G[SUP]1[/SUP], Garcin D[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus RNA promoter panhandle structures are believed to be sensed by RIG-I. The occurrence of mismatches in this dsRNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation, and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26446607 [PubMed - as supplied by publisher]
[h=1]Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation.[/h] Anchisi S[SUP]1[/SUP], Guerra J[SUP]1[/SUP], Mottet-Osman G[SUP]1[/SUP], Garcin D[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza virus RNA promoter panhandle structures are believed to be sensed by RIG-I. The occurrence of mismatches in this dsRNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation, and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26446607 [PubMed - as supplied by publisher]