tetano
Editor, Senior Moderator
Minerva Med
. 2022 Feb 14.
doi: 10.23736/S0026-4806.22.08026-0. Online ahead of print.
Co-infections in critically ill adults with severe acute respiratory syndrome coronavirus 2 infection. An italian multi-centre prospective study
Vincenzo Damico[SUP] 1 [/SUP], Liana Murano[SUP] 2 [/SUP], Viola Margosio[SUP] 3 [/SUP], Mauro Teli[SUP] 3 [/SUP], Clara Ripamonti[SUP] 3 [/SUP], Giuseppe Demoro[SUP] 4 [/SUP], Antonella D'Alessandro[SUP] 5 [/SUP], Giuseppe Russello[SUP] 6 [/SUP]
Affiliations
Abstract
Background: To date, few studies have described Hospital-acquired infections (HAIs) during COVID-19 outbreak. To examine the incidence of HAIs in critically ill adult patients with SARS-COV-2 infection and to observe risk factors, and the impact on outcome of HAI.
Methods: A prospective multicenter study was conducted that included adult patients with SARS-COV-2 infection admitted to 18 Italian Intensive Care Units from September 2020 to November 2021.
Results: A total of 589 patients were included. A total of 233 patients were diagnosed with at least 1 HAI (39.6%). The co-infection/co-colonisation rate > 48 hours after admission was 31.0 per 1,000 person-days (95% CI 18.8 - 34.8). Age, length of ICU stay > 7 days, obesity, type 2 diabetes mellitus, cardiovascular disease, inserted central venous catheter, intubation, APACHE II score > 25, mechanical ventilation (MV) > 48 hours, obesity and inserted urinary catheter are associated outcomes for infection aquisition. The overall mortality rate of patients was found to be significantly higher in patients who had acquired a HAI (RR= 4.37; 95% CI = 3.30 - 5.78; p < .001).
Conclusions: Associated factors for HAI acquisition and mortality in ICU patients were identified and cause for revision of existing infection control policies.
. 2022 Feb 14.
doi: 10.23736/S0026-4806.22.08026-0. Online ahead of print.
Co-infections in critically ill adults with severe acute respiratory syndrome coronavirus 2 infection. An italian multi-centre prospective study
Vincenzo Damico[SUP] 1 [/SUP], Liana Murano[SUP] 2 [/SUP], Viola Margosio[SUP] 3 [/SUP], Mauro Teli[SUP] 3 [/SUP], Clara Ripamonti[SUP] 3 [/SUP], Giuseppe Demoro[SUP] 4 [/SUP], Antonella D'Alessandro[SUP] 5 [/SUP], Giuseppe Russello[SUP] 6 [/SUP]
Affiliations
- PMID: 35156788
- DOI: 10.23736/S0026-4806.22.08026-0
Abstract
Background: To date, few studies have described Hospital-acquired infections (HAIs) during COVID-19 outbreak. To examine the incidence of HAIs in critically ill adult patients with SARS-COV-2 infection and to observe risk factors, and the impact on outcome of HAI.
Methods: A prospective multicenter study was conducted that included adult patients with SARS-COV-2 infection admitted to 18 Italian Intensive Care Units from September 2020 to November 2021.
Results: A total of 589 patients were included. A total of 233 patients were diagnosed with at least 1 HAI (39.6%). The co-infection/co-colonisation rate > 48 hours after admission was 31.0 per 1,000 person-days (95% CI 18.8 - 34.8). Age, length of ICU stay > 7 days, obesity, type 2 diabetes mellitus, cardiovascular disease, inserted central venous catheter, intubation, APACHE II score > 25, mechanical ventilation (MV) > 48 hours, obesity and inserted urinary catheter are associated outcomes for infection aquisition. The overall mortality rate of patients was found to be significantly higher in patients who had acquired a HAI (RR= 4.37; 95% CI = 3.30 - 5.78; p < .001).
Conclusions: Associated factors for HAI acquisition and mortality in ICU patients were identified and cause for revision of existing infection control policies.