tetano
Editor, Senior Moderator
Minerva Endocrinol (Torino)
. 2022 Mar 10.
doi: 10.23736/S2724-6507.22.03789-7. Online ahead of print.
Serum Galectin-3 and Aldosterone: potential biomarkers of cardiac complications in patients with COVID-19
Alessandro Cannavo[SUP] 1 [/SUP], Daniela Liccardo[SUP] 2 [/SUP], Monica Gelzo[SUP] 3 4 [/SUP], Felice Amato[SUP] 3 4 [/SUP], Ivan Gentile[SUP] 5 [/SUP], Biagio Pinchera[SUP] 5 [/SUP], Grazia D Femminella[SUP] 1 [/SUP], Roberto Parrella[SUP] 6 [/SUP], Annunziata DE Rosa[SUP] 6 [/SUP], Giuseppina Gambino[SUP] 1 [/SUP], Federica Marzano[SUP] 7 [/SUP], Nicola Ferrara[SUP] 1 8 [/SUP], Nazareno Paolocci[SUP] 9 10 [/SUP], Giuseppe Rengo[SUP] 11 8 [/SUP], Giuseppe Castaldo[SUP] 3 4 [/SUP]
Affiliations
Abstract
Background: Despite severe acute respiratory syndrome (SARS)-Coronavirus (CoV2) primarily targeting the lungs, the heart represents another critical virus target. Thus, the identification of SARS-CoV-2 disease of 2019 (COVID-19)-associated biomarkers would be beneficial to stratify prognosis and the risk of developing cardiac complications. Aldosterone and galectin-3 promote fibrosis and inflammation and are considered a prognostic biomarker of lung and adverse cardiac remodeling. Here, we tested whether galectin-3 and aldosterone levels can predict adverse cardiac outcomes in COVID-19 patients.
Methods: To this aim, we assessed galectin-3 and aldosterone serum levels in 51 patients diagnosed with COVID-19, using a population of 19 healthy subjects as controls. In in vitro studies, we employed 3T3 fibroblasts to assess the potential roles of aldosterone and galectin-3 in fibroblast activation.
Results: Serum galectin-3 levels were more elevated in COVID-19 patients than healthy controls and correlated with COVID-19 severity classification and cardiac Troponin-I (cTnI) serum levels. Furthermore, we observed an augmented secretion of aldosterone in COVID-19 patients. This adrenal hormone is a direct stimulator of galectin-3 secretion; therefore, we surmised that this axis could perpetrate fibrosis and adverse remodeling in these subjects. Thus, we stimulated fibroblasts with 10% of serum from COVID-19 patients. This challenge markedly rose the expression of smooth muscle alpha (α)-2 actin (ACTA2), a myofibroblast marker.
Conclusions: Our study suggests that COVID-19 can affect cardiac structure and function by triggering aldosterone and galectin-3 release that may serve as prognostic and therapeutic biomarkers while monitoring the course of cardiac complications in patients suffering from COVID-19.
. 2022 Mar 10.
doi: 10.23736/S2724-6507.22.03789-7. Online ahead of print.
Serum Galectin-3 and Aldosterone: potential biomarkers of cardiac complications in patients with COVID-19
Alessandro Cannavo[SUP] 1 [/SUP], Daniela Liccardo[SUP] 2 [/SUP], Monica Gelzo[SUP] 3 4 [/SUP], Felice Amato[SUP] 3 4 [/SUP], Ivan Gentile[SUP] 5 [/SUP], Biagio Pinchera[SUP] 5 [/SUP], Grazia D Femminella[SUP] 1 [/SUP], Roberto Parrella[SUP] 6 [/SUP], Annunziata DE Rosa[SUP] 6 [/SUP], Giuseppina Gambino[SUP] 1 [/SUP], Federica Marzano[SUP] 7 [/SUP], Nicola Ferrara[SUP] 1 8 [/SUP], Nazareno Paolocci[SUP] 9 10 [/SUP], Giuseppe Rengo[SUP] 11 8 [/SUP], Giuseppe Castaldo[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35266671
- DOI: 10.23736/S2724-6507.22.03789-7
Abstract
Background: Despite severe acute respiratory syndrome (SARS)-Coronavirus (CoV2) primarily targeting the lungs, the heart represents another critical virus target. Thus, the identification of SARS-CoV-2 disease of 2019 (COVID-19)-associated biomarkers would be beneficial to stratify prognosis and the risk of developing cardiac complications. Aldosterone and galectin-3 promote fibrosis and inflammation and are considered a prognostic biomarker of lung and adverse cardiac remodeling. Here, we tested whether galectin-3 and aldosterone levels can predict adverse cardiac outcomes in COVID-19 patients.
Methods: To this aim, we assessed galectin-3 and aldosterone serum levels in 51 patients diagnosed with COVID-19, using a population of 19 healthy subjects as controls. In in vitro studies, we employed 3T3 fibroblasts to assess the potential roles of aldosterone and galectin-3 in fibroblast activation.
Results: Serum galectin-3 levels were more elevated in COVID-19 patients than healthy controls and correlated with COVID-19 severity classification and cardiac Troponin-I (cTnI) serum levels. Furthermore, we observed an augmented secretion of aldosterone in COVID-19 patients. This adrenal hormone is a direct stimulator of galectin-3 secretion; therefore, we surmised that this axis could perpetrate fibrosis and adverse remodeling in these subjects. Thus, we stimulated fibroblasts with 10% of serum from COVID-19 patients. This challenge markedly rose the expression of smooth muscle alpha (α)-2 actin (ACTA2), a myofibroblast marker.
Conclusions: Our study suggests that COVID-19 can affect cardiac structure and function by triggering aldosterone and galectin-3 release that may serve as prognostic and therapeutic biomarkers while monitoring the course of cardiac complications in patients suffering from COVID-19.