tetano
Editor, Senior Moderator
Midwifery
. 2021 Aug 25;102:103128.
doi: 10.1016/j.midw.2021.103128. Online ahead of print.
Relationship between coronavirus disease 2019 in pregnancy and maternal and fetal outcomes: Retrospective analytical cohort study
Zahra Alipour[SUP] 1 [/SUP], Parisa Samadi[SUP] 2 [/SUP], Narges Eskandari[SUP] 1 [/SUP], Maryam Ghaedrahmati[SUP] 3 [/SUP], Mostafa Vahedian[SUP] 4 [/SUP], Zohre Khalajinia[SUP] 1 [/SUP], Ali Mastanijahroodi[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused many deaths and complications worldwide. However, limited data are available about COVID-19 during pregnancy. This study aimed to assess the epidemiological and clinical features of COVID-19, and the adverse maternal and fetal outcomes.
Design: This retrospective analytical cohort study was conducted on all pregnant women with confirmed COVID-19 at Nekouei-Hedayati-Forghani Hospital in Qom, Iran from 15 March 2020 to 15 November 2020. For the same period, 165 pregnant women who did not have COVID-19 were selected at random and included in this study. All epidemiological and clinical features were collected from the medical records of the participants. A logistic regression model was used to determine associations between COVID-19 in pregnancy and maternal and fetal outcomes.
Findings: The most common symptoms reported by pregnant women with COVID-19 were shortness of breath (60.9%), dry cough (59%) and fever (42.9%). After adjustment for potential confounding factors, COVID-19 in pregnancy was associated with a significantly higher risk of admission to the intensive care unit (ICU) [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.23-31], caesarean section (OR 0.45, 95 CI 0.25-1.03), preterm birth (OR 3.01, 95% CI 1.4-6.54), fetal distress (OR 5.7, 95% CI 2.13-15.59) and admission to the neonatal intensive care unit (NICU) (OR 3.04, 95% CI 1.21-7.70).
Key conclusions: COVID-19 is associated with adverse maternal and fetal outcomes, including ICU admission, caesarean section, fetal distress, preterm birth and NICU admission.
Keywords: Coronavirus pneumonia; Epidemiological characteristics; Fetal outcomes; Maternal outcomes; Pregnancy; Retrospective study.
. 2021 Aug 25;102:103128.
doi: 10.1016/j.midw.2021.103128. Online ahead of print.
Relationship between coronavirus disease 2019 in pregnancy and maternal and fetal outcomes: Retrospective analytical cohort study
Zahra Alipour[SUP] 1 [/SUP], Parisa Samadi[SUP] 2 [/SUP], Narges Eskandari[SUP] 1 [/SUP], Maryam Ghaedrahmati[SUP] 3 [/SUP], Mostafa Vahedian[SUP] 4 [/SUP], Zohre Khalajinia[SUP] 1 [/SUP], Ali Mastanijahroodi[SUP] 1 [/SUP]
Affiliations
- PMID: 34474247
- DOI: 10.1016/j.midw.2021.103128
Abstract
Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused many deaths and complications worldwide. However, limited data are available about COVID-19 during pregnancy. This study aimed to assess the epidemiological and clinical features of COVID-19, and the adverse maternal and fetal outcomes.
Design: This retrospective analytical cohort study was conducted on all pregnant women with confirmed COVID-19 at Nekouei-Hedayati-Forghani Hospital in Qom, Iran from 15 March 2020 to 15 November 2020. For the same period, 165 pregnant women who did not have COVID-19 were selected at random and included in this study. All epidemiological and clinical features were collected from the medical records of the participants. A logistic regression model was used to determine associations between COVID-19 in pregnancy and maternal and fetal outcomes.
Findings: The most common symptoms reported by pregnant women with COVID-19 were shortness of breath (60.9%), dry cough (59%) and fever (42.9%). After adjustment for potential confounding factors, COVID-19 in pregnancy was associated with a significantly higher risk of admission to the intensive care unit (ICU) [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.23-31], caesarean section (OR 0.45, 95 CI 0.25-1.03), preterm birth (OR 3.01, 95% CI 1.4-6.54), fetal distress (OR 5.7, 95% CI 2.13-15.59) and admission to the neonatal intensive care unit (NICU) (OR 3.04, 95% CI 1.21-7.70).
Key conclusions: COVID-19 is associated with adverse maternal and fetal outcomes, including ICU admission, caesarean section, fetal distress, preterm birth and NICU admission.
Keywords: Coronavirus pneumonia; Epidemiological characteristics; Fetal outcomes; Maternal outcomes; Pregnancy; Retrospective study.