Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution

Laidback Al · Sep 20, 2014

Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution

Jaffar A. Al-Tawfiq, Ziad A. Memish

Trends Microbiol. 2014 Aug 29. pii: S0966-842X(14)00157-7. doi: 10.1016/j.tim.2014.08.001. [Epub ahead of print] Review.
Publication stage: In Press Corrected Proof

Highlights

MERS-CoV continues to cause sporadic cases with amplification of cases in the healthcare setting.
Camels have been linked as an intermediate host.
Proper infection control measures are needed to prevent nosocomial outbreaks.

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV infection.

Copyright ? 2014 Elsevier Ltd. All rights reserved.

http://www.cell.com/trends/microbiology/abstract/S0966-842X(14)00157-7
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Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution

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