tetano
Editor, Senior Moderator
Microorganisms
. 2021 Oct 16;9(10):2159.
doi: 10.3390/microorganisms9102159.
The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio
Salma A Rizo-Téllez[SUP] 1 2 [/SUP], Lucia A Méndez-García[SUP] 1 [/SUP], Ana C Rivera-Rugeles[SUP] 3 [/SUP], Marcela Miranda-García[SUP] 1 [/SUP], Aarón N Manjarrez-Reyna[SUP] 1 [/SUP], Rebeca Viurcos-Sanabria[SUP] 1 2 [/SUP], Helena Solleiro-Villavicencio[SUP] 4 [/SUP], Enrique Becerril-Villanueva[SUP] 5 [/SUP], José D Carrillo-Ruíz[SUP] 6 7 8 [/SUP], Julian M Cota-Arce[SUP] 9 [/SUP], Angélica Álvarez-Lee[SUP] 9 [/SUP], Marco A De León-Nava[SUP] 9 [/SUP], Galileo Escobedo[SUP] 1 [/SUP]
Affiliations
Abstract
Laboratory parameters display limited accuracy in predicting mortality in coronavirus disease 2019 (COVID-19) patients, as with serum albumin. Emerging evidence suggests that cytokine serum values may enhance the predictive capacity of albumin, especially interleukin (IL)-15. We thus investigated whether the use of the IL-15-to-albumin ratio enables improving mortality prediction at hospital admission in a large group of COVID-19 patients. In this prospective cross-sectional study, we enrolled and followed up three hundred and seventy-eight patients with a COVID-19 diagnosis until hospital discharge or death. Two hundred and fifty-five patients survived, whereas one hundred and twenty-three died. Student's T-test revealed that non-survivors had a significant two-fold increase in the IL-15-to-albumin ratio compared to survivors (167.3 ± 63.8 versus 74.2 ± 28.5), a difference that was more evident than that found for IL-15 or albumin separately. Likewise, mortality prediction considerably improved when using the IL-15-to-albumin ratio with a cut-off point > 105.4, exhibiting an area under the receiver operating characteristic curve of 0.841 (95% Confidence Interval, 0.725-0.922, p < 0.001). As we outlined here, this is the first study showing that combining IL-15 serum values with albumin improves mortality prediction in COVID-19 patients.
Keywords: COVID-19; IL-15; SARS-CoV-2; albumin; mortality; prognosis.
. 2021 Oct 16;9(10):2159.
doi: 10.3390/microorganisms9102159.
The Combined Use of Cytokine Serum Values with Laboratory Parameters Improves Mortality Prediction of COVID-19 Patients: The Interleukin-15-to-Albumin Ratio
Salma A Rizo-Téllez[SUP] 1 2 [/SUP], Lucia A Méndez-García[SUP] 1 [/SUP], Ana C Rivera-Rugeles[SUP] 3 [/SUP], Marcela Miranda-García[SUP] 1 [/SUP], Aarón N Manjarrez-Reyna[SUP] 1 [/SUP], Rebeca Viurcos-Sanabria[SUP] 1 2 [/SUP], Helena Solleiro-Villavicencio[SUP] 4 [/SUP], Enrique Becerril-Villanueva[SUP] 5 [/SUP], José D Carrillo-Ruíz[SUP] 6 7 8 [/SUP], Julian M Cota-Arce[SUP] 9 [/SUP], Angélica Álvarez-Lee[SUP] 9 [/SUP], Marco A De León-Nava[SUP] 9 [/SUP], Galileo Escobedo[SUP] 1 [/SUP]
Affiliations
- PMID: 34683480
- PMCID: PMC8539806
- DOI: 10.3390/microorganisms9102159
Abstract
Laboratory parameters display limited accuracy in predicting mortality in coronavirus disease 2019 (COVID-19) patients, as with serum albumin. Emerging evidence suggests that cytokine serum values may enhance the predictive capacity of albumin, especially interleukin (IL)-15. We thus investigated whether the use of the IL-15-to-albumin ratio enables improving mortality prediction at hospital admission in a large group of COVID-19 patients. In this prospective cross-sectional study, we enrolled and followed up three hundred and seventy-eight patients with a COVID-19 diagnosis until hospital discharge or death. Two hundred and fifty-five patients survived, whereas one hundred and twenty-three died. Student's T-test revealed that non-survivors had a significant two-fold increase in the IL-15-to-albumin ratio compared to survivors (167.3 ± 63.8 versus 74.2 ± 28.5), a difference that was more evident than that found for IL-15 or albumin separately. Likewise, mortality prediction considerably improved when using the IL-15-to-albumin ratio with a cut-off point > 105.4, exhibiting an area under the receiver operating characteristic curve of 0.841 (95% Confidence Interval, 0.725-0.922, p < 0.001). As we outlined here, this is the first study showing that combining IL-15 serum values with albumin improves mortality prediction in COVID-19 patients.
Keywords: COVID-19; IL-15; SARS-CoV-2; albumin; mortality; prognosis.