tetano
Editor, Senior Moderator
Microorganisms
. 2021 Mar 4;9(3):525.
doi: 10.3390/microorganisms9030525.
SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention
Alessio Danilo Inchingolo[SUP] 1 [/SUP], Angelo Michele Inchingolo[SUP] 1 [/SUP], Ioana Roxana Bordea[SUP] 2 [/SUP], Giuseppina Malcangi[SUP] 1 [/SUP], Edit Xhajanka[SUP] 3 [/SUP], Antonio Scarano[SUP] 4 [/SUP], Felice Lorusso[SUP] 4 [/SUP], Marco Farronato[SUP] 5 [/SUP], Gianluca Martino Tartaglia[SUP] 5 [/SUP], Ciro Gargiulo Isacco[SUP] 1 6 7 [/SUP], Grazia Marinelli[SUP] 1 [/SUP], Maria Teresa D'Oria[SUP] 1 8 [/SUP], Denisa Hazballa[SUP] 1 9 [/SUP], Luigi Santacroce[SUP] 1 [/SUP], Andrea Ballini[SUP] 10 11 [/SUP], Maria Contaldo[SUP] 12 [/SUP], Francesco Inchingolo[SUP] 1 [/SUP], Gianna Dipalma[SUP] 1 [/SUP]
Affiliations
Abstract
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a high-risk viral agent involved in the recent pandemic stated worldwide by the World Health Organization. The infection is correlated to a severe systemic and respiratory disease in many cases, which is clinically treated with a multi-drug pharmacological approach. The purpose of this investigation was to evaluate through a literature overview the effect of adjuvant therapies and supplements for the SARS-CoV-2 infection. The research has analyzed the advantage of the EK1C4, by also assessing the studies on the resveratrol, vitamin D, and melatonin as adjuvant supplements for long hauler patients' prognosis. The evaluated substances reported important benefits for the improvement of the immune system and as a potential inhibitor molecules against SARS-CoV-2, highlighting the use of sartans as therapy. The adjuvant supplements seem to create an advantage for the healing of the long hauler patients affected by chronic symptoms of constant chest and heart pain, intestinal disorders, headache, difficulty concentrating, memory loss, and tachycardia.
Keywords: COVID-19; SARS-CoV-2; cytokine storm syndrome; endovir stop spray; furin; microbiome; oral mucosa; pandemics; resveratrol; vaccines.
. 2021 Mar 4;9(3):525.
doi: 10.3390/microorganisms9030525.
SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention
Alessio Danilo Inchingolo[SUP] 1 [/SUP], Angelo Michele Inchingolo[SUP] 1 [/SUP], Ioana Roxana Bordea[SUP] 2 [/SUP], Giuseppina Malcangi[SUP] 1 [/SUP], Edit Xhajanka[SUP] 3 [/SUP], Antonio Scarano[SUP] 4 [/SUP], Felice Lorusso[SUP] 4 [/SUP], Marco Farronato[SUP] 5 [/SUP], Gianluca Martino Tartaglia[SUP] 5 [/SUP], Ciro Gargiulo Isacco[SUP] 1 6 7 [/SUP], Grazia Marinelli[SUP] 1 [/SUP], Maria Teresa D'Oria[SUP] 1 8 [/SUP], Denisa Hazballa[SUP] 1 9 [/SUP], Luigi Santacroce[SUP] 1 [/SUP], Andrea Ballini[SUP] 10 11 [/SUP], Maria Contaldo[SUP] 12 [/SUP], Francesco Inchingolo[SUP] 1 [/SUP], Gianna Dipalma[SUP] 1 [/SUP]
Affiliations
- PMID: 33806624
- DOI: 10.3390/microorganisms9030525
Abstract
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a high-risk viral agent involved in the recent pandemic stated worldwide by the World Health Organization. The infection is correlated to a severe systemic and respiratory disease in many cases, which is clinically treated with a multi-drug pharmacological approach. The purpose of this investigation was to evaluate through a literature overview the effect of adjuvant therapies and supplements for the SARS-CoV-2 infection. The research has analyzed the advantage of the EK1C4, by also assessing the studies on the resveratrol, vitamin D, and melatonin as adjuvant supplements for long hauler patients' prognosis. The evaluated substances reported important benefits for the improvement of the immune system and as a potential inhibitor molecules against SARS-CoV-2, highlighting the use of sartans as therapy. The adjuvant supplements seem to create an advantage for the healing of the long hauler patients affected by chronic symptoms of constant chest and heart pain, intestinal disorders, headache, difficulty concentrating, memory loss, and tachycardia.
Keywords: COVID-19; SARS-CoV-2; cytokine storm syndrome; endovir stop spray; furin; microbiome; oral mucosa; pandemics; resveratrol; vaccines.