tetano
Editor, Senior Moderator
Microorganisms
. 2020 Jul 2;8(7):E991.
doi: 10.3390/microorganisms8070991.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science
Ahmed Mostafa[SUP] 1 [/SUP], Ahmed Kandeil[SUP] 1 [/SUP], Mahmoud Shehata[SUP] 1 [/SUP], Rabeh El Shesheny[SUP] 1 2 [/SUP], Abdallah M Samy[SUP] 3 [/SUP], Ghazi Kayali[SUP] 4 5 [/SUP], Mohamed A Ali[SUP] 1 [/SUP]
Affiliations
Abstract
Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members of this family evolved to cross species barriers infecting humans and resulting in relatively high case fatality rates (CFR). Compared to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV, CFR = 10%) and pandemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CFR = 6%), the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has scored the highest CFR (approximately 35%). In this review, we systematically summarize the current state of scientific knowledge about MERS-CoV, including virology and origin, epidemiology, zoonotic mode of transmission, and potential therapeutic or prophylactic intervention modalities.
Keywords: MERS-CoV; coronavirus; epidemiology; zoonotic disease.
. 2020 Jul 2;8(7):E991.
doi: 10.3390/microorganisms8070991.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): State of the Science
Ahmed Mostafa[SUP] 1 [/SUP], Ahmed Kandeil[SUP] 1 [/SUP], Mahmoud Shehata[SUP] 1 [/SUP], Rabeh El Shesheny[SUP] 1 2 [/SUP], Abdallah M Samy[SUP] 3 [/SUP], Ghazi Kayali[SUP] 4 5 [/SUP], Mohamed A Ali[SUP] 1 [/SUP]
Affiliations
- PMID: 32630780
- DOI: 10.3390/microorganisms8070991
Abstract
Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members of this family evolved to cross species barriers infecting humans and resulting in relatively high case fatality rates (CFR). Compared to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV, CFR = 10%) and pandemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CFR = 6%), the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has scored the highest CFR (approximately 35%). In this review, we systematically summarize the current state of scientific knowledge about MERS-CoV, including virology and origin, epidemiology, zoonotic mode of transmission, and potential therapeutic or prophylactic intervention modalities.
Keywords: MERS-CoV; coronavirus; epidemiology; zoonotic disease.