tetano
Editor, Senior Moderator
Microorganisms
. 2020 Jul 24;8(8):E1106.
doi: 10.3390/microorganisms8081106.
Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study
Roberto de la Rica[SUP] 1 [/SUP], Marcio Borges[SUP] 1 2 [/SUP], Maria Aranda[SUP] 1 2 [/SUP], Alberto Del Castillo[SUP] 1 2 [/SUP], Antonia Socias[SUP] 1 2 [/SUP], Antoni Payeras[SUP] 3 [/SUP], Gemma Rialp[SUP] 2 4 [/SUP], Lorenzo Socias[SUP] 2 [/SUP], Lluis Masmiquel[SUP] 5 [/SUP], Marta Gonzalez-Freire[SUP] 5 [/SUP]
Affiliations
Abstract
There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. Forty-eight patients (27 non-ICU and 21 ICU) with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed (mean age, 66 years, [range, 33-88 years]; 67% males). There were no differences in age or sex among groups. Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). ICU patients had a higher prevalence of dyspnea compared to non-ICU patients (95% vs. 61%, p = 0.022). ICU-patients had lymphopenia as well as hypoalbuminemia. Lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < 0.001). Lower albumin levels were associated with poor prognosis measured as longer hospital length (r = -0.472, p < 0.001) and mortality (r = -0.424, p = 0.003). As of 28 April 2020, 10 patients (8 ICU and 2 non-ICU) have died (21% mortality), and while 100% of the non-ICU patients have been discharged, 33% of the ICU patients still remained hospitalized (5 in ICU and 2 had been transferred to ward). Critically ill patients with COVID-19 present lymphopenia, hypoalbuminemia and high levels of inflammation.
Keywords: COVID-19; albumin; inflammation.
. 2020 Jul 24;8(8):E1106.
doi: 10.3390/microorganisms8081106.
Low Albumin Levels Are Associated with Poorer Outcomes in a Case Series of COVID-19 Patients in Spain: A Retrospective Cohort Study
Roberto de la Rica[SUP] 1 [/SUP], Marcio Borges[SUP] 1 2 [/SUP], Maria Aranda[SUP] 1 2 [/SUP], Alberto Del Castillo[SUP] 1 2 [/SUP], Antonia Socias[SUP] 1 2 [/SUP], Antoni Payeras[SUP] 3 [/SUP], Gemma Rialp[SUP] 2 4 [/SUP], Lorenzo Socias[SUP] 2 [/SUP], Lluis Masmiquel[SUP] 5 [/SUP], Marta Gonzalez-Freire[SUP] 5 [/SUP]
Affiliations
- PMID: 32722020
- DOI: 10.3390/microorganisms8081106
Abstract
There is limited information available describing the clinical and epidemiological features of Spanish patients requiring hospitalization for coronavirus disease 2019 (COVID-19). In this observational study, we aimed to describe the clinical characteristics and epidemiological features of severe (non-ICU) and critically patients (ICU) with COVID-19 at triage, prior to hospitalization. Forty-eight patients (27 non-ICU and 21 ICU) with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were analyzed (mean age, 66 years, [range, 33-88 years]; 67% males). There were no differences in age or sex among groups. Initial symptoms included fever (100%), coughing (85%), dyspnea (76%), diarrhea (42%) and asthenia (21%). ICU patients had a higher prevalence of dyspnea compared to non-ICU patients (95% vs. 61%, p = 0.022). ICU-patients had lymphopenia as well as hypoalbuminemia. Lactate dehydrogenase (LDH), C-reactive protein (CRP), and procalcitonin were significantly higher in ICU patients compared to non-ICU (p < 0.001). Lower albumin levels were associated with poor prognosis measured as longer hospital length (r = -0.472, p < 0.001) and mortality (r = -0.424, p = 0.003). As of 28 April 2020, 10 patients (8 ICU and 2 non-ICU) have died (21% mortality), and while 100% of the non-ICU patients have been discharged, 33% of the ICU patients still remained hospitalized (5 in ICU and 2 had been transferred to ward). Critically ill patients with COVID-19 present lymphopenia, hypoalbuminemia and high levels of inflammation.
Keywords: COVID-19; albumin; inflammation.