tetano
Editor, Senior Moderator
Microorganisms
. 2021 Mar 3;9(3):521.
doi: 10.3390/microorganisms9030521.
Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX [SUP]?[/SUP] and BacterX [SUP]?[/SUP] Pro
Julia Koch-Heier[SUP] 1 [/SUP], Helen Hoffmann[SUP] 1 [/SUP], Michael Schindler[SUP] 2 [/SUP], Adrian Lussi[SUP] 3 4 [/SUP], Oliver Planz[SUP] 1 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic effects daily dental work. Therefore, infection control measures are necessary to prevent infection of dental personnel during dental treatments. The use of a preprocedural mouth rinse with chlorhexidine (CHX), cetylpyridinium chloride (CPC), or hydrogen peroxide (H[SUB]2[/SUB]O[SUB]2[/SUB]) solution for 30-60 s may reduce the viral load and may protect the personnel in a dental practice. In the present study the virucidal effect of the mouth rinsing solutions ViruProX[SUP]?[/SUP] with 0.05% CPC and 1.5% H[SUB]2[/SUB]O[SUB]2[/SUB] and BacterX[SUP]?[/SUP] pro containing 0.1% CHX, 0.05% CPC, and 0.005% sodium fluoride (F[SUP]-[/SUP]) was investigated in vitro. The mouth rinsing solutions successfully inactivated infectious SARS-CoV-2 particles, the causative agent of coronavirus disease 2019 (COVID-19), within 30 s. To determine the effective components, CHX, CPC, H[SUB]2[/SUB]O[SUB]2[/SUB], and a combination of CHX and CPC, were tested against SARS-CoV-2 in addition. While a combination of CPC and CHX as well as CPC alone led to a significant reduction of infectious viral particles, H[SUB]2[/SUB]O[SUB]2[/SUB] and CHX alone had no virucidal effect against SARS-CoV-2. It can be assumed that preprocedural rinsing of the mouth with ViruProX[SUP]?[/SUP] or BacterX[SUP]?[/SUP] pro will reduce the viral load in the oral cavity and could thus lower the transmission of SARS-CoV-2 in dental practice.
Keywords: BacterX? pro; SARS-CoV-2; ViruProX?; cetylpyridinium chloride; mouth rinsing solution.
. 2021 Mar 3;9(3):521.
doi: 10.3390/microorganisms9030521.
Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX [SUP]?[/SUP] and BacterX [SUP]?[/SUP] Pro
Julia Koch-Heier[SUP] 1 [/SUP], Helen Hoffmann[SUP] 1 [/SUP], Michael Schindler[SUP] 2 [/SUP], Adrian Lussi[SUP] 3 4 [/SUP], Oliver Planz[SUP] 1 [/SUP]
Affiliations
- PMID: 33802603
- DOI: 10.3390/microorganisms9030521
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic effects daily dental work. Therefore, infection control measures are necessary to prevent infection of dental personnel during dental treatments. The use of a preprocedural mouth rinse with chlorhexidine (CHX), cetylpyridinium chloride (CPC), or hydrogen peroxide (H[SUB]2[/SUB]O[SUB]2[/SUB]) solution for 30-60 s may reduce the viral load and may protect the personnel in a dental practice. In the present study the virucidal effect of the mouth rinsing solutions ViruProX[SUP]?[/SUP] with 0.05% CPC and 1.5% H[SUB]2[/SUB]O[SUB]2[/SUB] and BacterX[SUP]?[/SUP] pro containing 0.1% CHX, 0.05% CPC, and 0.005% sodium fluoride (F[SUP]-[/SUP]) was investigated in vitro. The mouth rinsing solutions successfully inactivated infectious SARS-CoV-2 particles, the causative agent of coronavirus disease 2019 (COVID-19), within 30 s. To determine the effective components, CHX, CPC, H[SUB]2[/SUB]O[SUB]2[/SUB], and a combination of CHX and CPC, were tested against SARS-CoV-2 in addition. While a combination of CPC and CHX as well as CPC alone led to a significant reduction of infectious viral particles, H[SUB]2[/SUB]O[SUB]2[/SUB] and CHX alone had no virucidal effect against SARS-CoV-2. It can be assumed that preprocedural rinsing of the mouth with ViruProX[SUP]?[/SUP] or BacterX[SUP]?[/SUP] pro will reduce the viral load in the oral cavity and could thus lower the transmission of SARS-CoV-2 in dental practice.
Keywords: BacterX? pro; SARS-CoV-2; ViruProX?; cetylpyridinium chloride; mouth rinsing solution.