tetano
Editor, Senior Moderator
Microorganisms
. 2021 Jun 21;9(6):1340.
doi: 10.3390/microorganisms9061340.
Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2
Jean-Louis Bayart[SUP] 1 [/SUP], Laure Morimont[SUP] 2 3 [/SUP], Mélanie Closset[SUP] 4 [/SUP], Grégoire Wieërs[SUP] 5 [/SUP], Tatiana Roy[SUP] 1 [/SUP], Vincent Gerin[SUP] 1 [/SUP], Marc Elsen[SUP] 6 [/SUP], Christine Eucher[SUP] 6 [/SUP], Sandrine Van Eeckhoudt[SUP] 7 [/SUP], Nathalie Ausselet[SUP] 8 [/SUP], Clara David[SUP] 3 [/SUP], François Mullier[SUP] 4 [/SUP], Jean-Michel Dogné[SUP] 2 [/SUP], Julien Favresse[SUP] 2 6 [/SUP], Jonathan Douxfils[SUP] 2 3 [/SUP]
Affiliations
Abstract
Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine.
Methods: Blood samples from 231 subjects were collected before and 14, 28, and 42 days following coronavirus disease 2019 (COVID-19) vaccination with BNT162b2. Anti-spike receptor-binding-domain protein (anti-Spike/RBD) immunoglobulin G (IgG) antibodies were measured at each time-point. Impact of age, sex, childbearing age status, hormonal therapy, blood group, body mass index and past-history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were assessed by multivariable analyses.
Results and conclusions: In naïve subjects, the level of anti-Spike/RBD antibodies gradually increased following administration of the first dose to reach the maximal response at day 28 and then plateauing at day 42. In vaccinated subjects with previous SARS-CoV-2 infection, the plateau was reached sooner (i.e., at day 14). In the naïve population, age had a significant negative impact on anti-Spike/RBD titers at days 14 and 28 while lower levels were observed for males at day 42, when corrected for other confounding factors. Body mass index (BMI) as well as B and AB blood groups had a significant impact in various subgroups on the early response at day 14 but no longer after. No significant confounding factors were highlighted in the previously infected group.
Keywords: BMI; BNT162b2; SARS-CoV-2; age; antibody; blood-group; gender; kinetic; serology; vaccine.
. 2021 Jun 21;9(6):1340.
doi: 10.3390/microorganisms9061340.
Confounding Factors Influencing the Kinetics and Magnitude of Serological Response Following Administration of BNT162b2
Jean-Louis Bayart[SUP] 1 [/SUP], Laure Morimont[SUP] 2 3 [/SUP], Mélanie Closset[SUP] 4 [/SUP], Grégoire Wieërs[SUP] 5 [/SUP], Tatiana Roy[SUP] 1 [/SUP], Vincent Gerin[SUP] 1 [/SUP], Marc Elsen[SUP] 6 [/SUP], Christine Eucher[SUP] 6 [/SUP], Sandrine Van Eeckhoudt[SUP] 7 [/SUP], Nathalie Ausselet[SUP] 8 [/SUP], Clara David[SUP] 3 [/SUP], François Mullier[SUP] 4 [/SUP], Jean-Michel Dogné[SUP] 2 [/SUP], Julien Favresse[SUP] 2 6 [/SUP], Jonathan Douxfils[SUP] 2 3 [/SUP]
Affiliations
- PMID: 34205564
- DOI: 10.3390/microorganisms9061340
Abstract
Background: Little is known about potential confounding factors influencing the humoral response in individuals having received the BNT162b2 vaccine.
Methods: Blood samples from 231 subjects were collected before and 14, 28, and 42 days following coronavirus disease 2019 (COVID-19) vaccination with BNT162b2. Anti-spike receptor-binding-domain protein (anti-Spike/RBD) immunoglobulin G (IgG) antibodies were measured at each time-point. Impact of age, sex, childbearing age status, hormonal therapy, blood group, body mass index and past-history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were assessed by multivariable analyses.
Results and conclusions: In naïve subjects, the level of anti-Spike/RBD antibodies gradually increased following administration of the first dose to reach the maximal response at day 28 and then plateauing at day 42. In vaccinated subjects with previous SARS-CoV-2 infection, the plateau was reached sooner (i.e., at day 14). In the naïve population, age had a significant negative impact on anti-Spike/RBD titers at days 14 and 28 while lower levels were observed for males at day 42, when corrected for other confounding factors. Body mass index (BMI) as well as B and AB blood groups had a significant impact in various subgroups on the early response at day 14 but no longer after. No significant confounding factors were highlighted in the previously infected group.
Keywords: BMI; BNT162b2; SARS-CoV-2; age; antibody; blood-group; gender; kinetic; serology; vaccine.