tetano
Editor, Senior Moderator
Arch Virol. 2018 Apr 5. doi: 10.1007/s00705-018-3833-7. [Epub ahead of print]
[h=1]Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017.[/h] Nagy A[SUP]1[/SUP], D?n ?[SUP]2[/SUP], Čern?kov? L[SUP]3[/SUP], Vit?skov? E[SUP]3[/SUP], Křivda V[SUP]3[/SUP], Horn?čkov? J[SUP]3[/SUP], Masopust R[SUP]3[/SUP], Sedl?k K[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
PMID: 29623433 DOI: 10.1007/s00705-018-3833-7
[h=1]Microevolution and independent incursions as main forces shaping H5 Hemagglutinin diversity during a H5N8/H5N5 highly pathogenic avian influenza outbreak in Czech Republic in 2017.[/h] Nagy A[SUP]1[/SUP], D?n ?[SUP]2[/SUP], Čern?kov? L[SUP]3[/SUP], Vit?skov? E[SUP]3[/SUP], Křivda V[SUP]3[/SUP], Horn?čkov? J[SUP]3[/SUP], Masopust R[SUP]3[/SUP], Sedl?k K[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Here, we present a comprehensive analysis of the H5N8/H5N5 highly pathogenic avian influenza (HPAI) virus strains detected in the Czech Republic during an outbreak in 2017. Network analysis of the H5 Hemagglutinin (HA) from 99% of the outbreak localities suggested that the diversity of the Czech H5N8/H5N5 viruses was influenced by two basic forces: local microevolution and independent incursions. The geographical occurrence of the central node H5 HA sequences revealed three eco-regions, which apparently played an important role in the origin and further spread of the local H5N8/HPAI variants across the country. A plausible explanation for the observed pattern of diversity is also provided.
PMID: 29623433 DOI: 10.1007/s00705-018-3833-7