tetano
Editor, Senior Moderator
Microbiol Spectr
. 2024 Jan 8:e0329123.
doi: 10.1128/spectrum.03291-23. Online ahead of print. Recurrent SARS-CoV-2 mutations at Spike D796 evade antibodies from pre-Omicron convalescent and vaccinated subjects
Evan A Elko[SUP] #[/SUP][SUP] 1 [/SUP], Heather L Mead[SUP] #[/SUP][SUP] 2 [/SUP], Georgia A Nelson[SUP] 2 [/SUP], John A Zaia[SUP] 3 [/SUP], Jason T Ladner[SUP] 1 [/SUP], John A Altin[SUP] 2 [/SUP]
Affiliations
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved substantially through the coronavirus disease 2019 (COVID-19) pandemic: understanding the drivers and consequences of this evolution is essential for projecting the course of the pandemic and developing new countermeasures. Here, we study the immunological effects of a particular mutation present in the Spike protein of all Omicron strains and find that it prevents the efficient binding of a class of antibodies raised by pre-Omicron vaccination and infection. These findings reveal a novel consequence of a poorly understood Omicron mutation and shed light on the drivers and effects of SARS-CoV-2 evolution.
Keywords: assay development; coronavirus; immune evasion; vaccination; viral immunity.
. 2024 Jan 8:e0329123.
doi: 10.1128/spectrum.03291-23. Online ahead of print. Recurrent SARS-CoV-2 mutations at Spike D796 evade antibodies from pre-Omicron convalescent and vaccinated subjects
Evan A Elko[SUP] #[/SUP][SUP] 1 [/SUP], Heather L Mead[SUP] #[/SUP][SUP] 2 [/SUP], Georgia A Nelson[SUP] 2 [/SUP], John A Zaia[SUP] 3 [/SUP], Jason T Ladner[SUP] 1 [/SUP], John A Altin[SUP] 2 [/SUP]
Affiliations
- PMID: 38189279
- DOI: 10.1128/spectrum.03291-23
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved substantially through the coronavirus disease 2019 (COVID-19) pandemic: understanding the drivers and consequences of this evolution is essential for projecting the course of the pandemic and developing new countermeasures. Here, we study the immunological effects of a particular mutation present in the Spike protein of all Omicron strains and find that it prevents the efficient binding of a class of antibodies raised by pre-Omicron vaccination and infection. These findings reveal a novel consequence of a poorly understood Omicron mutation and shed light on the drivers and effects of SARS-CoV-2 evolution.
Keywords: assay development; coronavirus; immune evasion; vaccination; viral immunity.