tetano
Editor, Senior Moderator
Microbes Infect. 2020 Feb 19. pii: S1286-4579(20)30030-7. doi: 10.1016/j.micinf.2020.02.002. [Epub ahead of print] [h=1]The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future.[/h]
Li JY[SUP]1[/SUP], You Z[SUP]2[/SUP], Wang Q[SUP]3[/SUP], Zhou ZJ[SUP]4[/SUP], Qiu Y[SUP]5[/SUP], Luo R[SUP]6[/SUP], Ge XY[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections. Intensive research on the novel emerging human infectious coronaviruses is urgently needed to elucidate their route of transmission and pathogenic mechanisms, and to identify potential drug targets, which would promote the development of effective preventive and therapeutic countermeasures. Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV.
Copyright ? 2020. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] 2019-nCoV; ACE2; SARS-CoV; bat; pneumonia; spike
PMID: 32087334 DOI: 10.1016/j.micinf.2020.02.002
Li JY[SUP]1[/SUP], You Z[SUP]2[/SUP], Wang Q[SUP]3[/SUP], Zhou ZJ[SUP]4[/SUP], Qiu Y[SUP]5[/SUP], Luo R[SUP]6[/SUP], Ge XY[SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections. Intensive research on the novel emerging human infectious coronaviruses is urgently needed to elucidate their route of transmission and pathogenic mechanisms, and to identify potential drug targets, which would promote the development of effective preventive and therapeutic countermeasures. Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV.
Copyright ? 2020. Published by Elsevier Masson SAS.
[h=4]KEYWORDS:[/h] 2019-nCoV; ACE2; SARS-CoV; bat; pneumonia; spike
PMID: 32087334 DOI: 10.1016/j.micinf.2020.02.002