tetano
Editor, Senior Moderator
Microbes Infect
. 2023 Sep 19;105228.
doi: 10.1016/j.micinf.2023.105228. Online ahead of print. Identification of SARS-CoV-2 m6A modification sites correlate with viral pathogenicity
Ke Liu[SUP] 1 [/SUP], Ying-Zi Zhang[SUP] 1 [/SUP], Hui Yin[SUP] 2 [/SUP], Lu-Lu Yu[SUP] 3 [/SUP], Jia-Jia Cui[SUP] 4 [/SUP], Ji-Ye Yin[SUP] 5 [/SUP], Chen-Hui Luo[SUP] 6 [/SUP], Cheng-Xian Guo[SUP] 7 [/SUP]
Affiliations
It has recently been found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) m6A modifications can affect viral replication and function. However, no studies to date have shown a correlation between SARS-CoV-2 m6A modifications and viral pathogenicity. In this study, we analyzed m6A modification in 2,190,667 SARS-CoV-2 genomic RNAs. m6A modifications of SARS-CoV-2 from different lineages, causing mild or severe COVID-19 and showing breakthrough for different vaccines were analyzed to explore correlations with viral pathogenicity. The results suggested that the presence of more m6A modifications in the SARS-CoV-2 N region (positive strand) correlates with weaker pathogenicity. In addition, we identified three m6A modification sites correlating with weak pathogenicity (924 in ORF1ab, 15659 in ORF1ab, 28288 in N, 28633 in N and 29385 in N, 29707 in 3'UTR) and one with strong pathogenicity (74 in 5'UTR). These results provide new information for understanding the prevalence of SARS-CoV-2 and controlling the virus.
Keywords: COVID-19; SARS-CoV-2; breakthrough infection; m6A; β-coronaviruses.
. 2023 Sep 19;105228.
doi: 10.1016/j.micinf.2023.105228. Online ahead of print. Identification of SARS-CoV-2 m6A modification sites correlate with viral pathogenicity
Ke Liu[SUP] 1 [/SUP], Ying-Zi Zhang[SUP] 1 [/SUP], Hui Yin[SUP] 2 [/SUP], Lu-Lu Yu[SUP] 3 [/SUP], Jia-Jia Cui[SUP] 4 [/SUP], Ji-Ye Yin[SUP] 5 [/SUP], Chen-Hui Luo[SUP] 6 [/SUP], Cheng-Xian Guo[SUP] 7 [/SUP]
Affiliations
- PMID: 37734532
- DOI: 10.1016/j.micinf.2023.105228
It has recently been found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) m6A modifications can affect viral replication and function. However, no studies to date have shown a correlation between SARS-CoV-2 m6A modifications and viral pathogenicity. In this study, we analyzed m6A modification in 2,190,667 SARS-CoV-2 genomic RNAs. m6A modifications of SARS-CoV-2 from different lineages, causing mild or severe COVID-19 and showing breakthrough for different vaccines were analyzed to explore correlations with viral pathogenicity. The results suggested that the presence of more m6A modifications in the SARS-CoV-2 N region (positive strand) correlates with weaker pathogenicity. In addition, we identified three m6A modification sites correlating with weak pathogenicity (924 in ORF1ab, 15659 in ORF1ab, 28288 in N, 28633 in N and 29385 in N, 29707 in 3'UTR) and one with strong pathogenicity (74 in 5'UTR). These results provide new information for understanding the prevalence of SARS-CoV-2 and controlling the virus.
Keywords: COVID-19; SARS-CoV-2; breakthrough infection; m6A; β-coronaviruses.