tetano
Editor, Senior Moderator
Microbes Infect
. 2020 May 10;S1286-4579(20)30082-4.
doi: 10.1016/j.micinf.2020.05.004. Online ahead of print.
From SARS-CoV to SARS-CoV-2: Safety and Broad-Spectrum Are Important for Coronavirus Vaccine Development
Cuiqing Ma[SUP] 1 [/SUP], Shan Su[SUP] 2 [/SUP], Jiachao Wang[SUP] 1 [/SUP], Lin Wei[SUP] 1 [/SUP], Lanying Du[SUP] 3 [/SUP], Shibo Jiang[SUP] 4 [/SUP]
Affiliations
Abstract
The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.
Keywords: 2019-nCoV; Cross-protection; HCoV-19; Human coronavirus; SARS-CoV; SARS-CoV-2; Vaccine.
. 2020 May 10;S1286-4579(20)30082-4.
doi: 10.1016/j.micinf.2020.05.004. Online ahead of print.
From SARS-CoV to SARS-CoV-2: Safety and Broad-Spectrum Are Important for Coronavirus Vaccine Development
Cuiqing Ma[SUP] 1 [/SUP], Shan Su[SUP] 2 [/SUP], Jiachao Wang[SUP] 1 [/SUP], Lin Wei[SUP] 1 [/SUP], Lanying Du[SUP] 3 [/SUP], Shibo Jiang[SUP] 4 [/SUP]
Affiliations
- PMID: 32437926
- DOI: 10.1016/j.micinf.2020.05.004
Abstract
The global pandemic of COVID-19 caused by SARS-CoV-2 (also known as 2019-nCoV and HCoV-19) has posed serious threats to public health and economic stability worldwide, thus calling for development of vaccines against SARS-CoV-2 and other emerging and reemerging coronaviruses. Since SARS-CoV-2 and SARS-CoV have high similarity of their genomic sequences and share the same cellular receptor (ACE2), it is essential to learn the lessons and experiences from the development of SARS-CoV vaccines for the development of SARS-CoV-2 vaccines. In this review, we summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS-CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.
Keywords: 2019-nCoV; Cross-protection; HCoV-19; Human coronavirus; SARS-CoV; SARS-CoV-2; Vaccine.