tetano
Editor, Senior Moderator
Microbes Infect
. 2021 Oct 28;104895.
doi: 10.1016/j.micinf.2021.104895. Online ahead of print.
Combination of Baloxavir and Oseltamivir for Treatment of Severe Influenza Infection in Hematopoietic Cell Transplant Recipients: A Novel Treatment Strategy for a High-risk Population
Georgios Angelidakis[SUP] 1 [/SUP], Fareed Khawaja[SUP] 1 [/SUP], Victor E Mulanovich[SUP] 1 [/SUP], Natalie Dailey Garnes[SUP] 1 [/SUP], Ella Ariza Heredia[SUP] 1 [/SUP], Roy F Chemaly[SUP] 2 [/SUP]
Affiliations
Abstract
Baloxavir, a cap-dependent endonuclease inhibitor, was recently approved for treatment of severe influenza infections. Combining baloxavir with oseltamivir has been proposed to increase the response rate. We report 2 hematopoietic cell transplant recipients with severe influenza infections who were treated with this combination and discuss possible reasons for their different responses.
Keywords: Baloxavir; Combination therapy; HCT; Influenza; Oseltamivir.
. 2021 Oct 28;104895.
doi: 10.1016/j.micinf.2021.104895. Online ahead of print.
Combination of Baloxavir and Oseltamivir for Treatment of Severe Influenza Infection in Hematopoietic Cell Transplant Recipients: A Novel Treatment Strategy for a High-risk Population
Georgios Angelidakis[SUP] 1 [/SUP], Fareed Khawaja[SUP] 1 [/SUP], Victor E Mulanovich[SUP] 1 [/SUP], Natalie Dailey Garnes[SUP] 1 [/SUP], Ella Ariza Heredia[SUP] 1 [/SUP], Roy F Chemaly[SUP] 2 [/SUP]
Affiliations
- PMID: 34756990
- DOI: 10.1016/j.micinf.2021.104895
Abstract
Baloxavir, a cap-dependent endonuclease inhibitor, was recently approved for treatment of severe influenza infections. Combining baloxavir with oseltamivir has been proposed to increase the response rate. We report 2 hematopoietic cell transplant recipients with severe influenza infections who were treated with this combination and discuss possible reasons for their different responses.
Keywords: Baloxavir; Combination therapy; HCT; Influenza; Oseltamivir.