tetano
Editor, Senior Moderator
Microb Pathog
. 2021 Jul 23;105105.
doi: 10.1016/j.micpath.2021.105105. Online ahead of print.
Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection
Suresh Kumar Kali[SUP] 1 [/SUP], Peter Dröge[SUP] 2 [/SUP], Priyatharshini Murugan[SUP] 3 [/SUP]
Affiliations
Abstract
COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19.
Keywords: Coronavirus disease 2019; Innate immunity; Interferon β monotherapy; Severe acute respiratory syndrome; Type I Interferon.
. 2021 Jul 23;105105.
doi: 10.1016/j.micpath.2021.105105. Online ahead of print.
Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection
Suresh Kumar Kali[SUP] 1 [/SUP], Peter Dröge[SUP] 2 [/SUP], Priyatharshini Murugan[SUP] 3 [/SUP]
Affiliations
- PMID: 34311016
- DOI: 10.1016/j.micpath.2021.105105
Abstract
COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19.
Keywords: Coronavirus disease 2019; Innate immunity; Interferon β monotherapy; Severe acute respiratory syndrome; Type I Interferon.