Methods Mol Biol . Towards Determining the Epitopes of the Structural Proteins of SARS-CoV-2

[tetano]

Methods Mol Biol


. 2022;2410:265-272.
doi: 10.1007/978-1-0716-1884-4_12.
Towards Determining the Epitopes of the Structural Proteins of SARS-CoV-2


Sunil Thomas[SUP] 1 [/SUP]



Affiliations

• PMID: 34914051
• DOI: 10.1007/978-1-0716-1884-4_12

Abstract

COVID-19 caused by SARS-CoV-2, an RNA coronavirus has impacted the health and economy of all the countries. The virus has wide host adaptability and causes severe diseases in humans and animals. The major structural proteins of SARS-CoV-2 include spike (S), envelop (E), membrane (M), and nucleocapsid (N). The current vaccines are based on the S protein. The emergence of variants of SARS-CoV-2 has renewed interest in the use of additional structural proteins for the development of diagnostics and vaccines. Knowledge of B cell epitopes and MHC-I binding regions of the structural proteins of SARS-CoV-2 is essential in the development of effective diagnostics and therapies. This chapter provides information on the epitopes of the structural proteins of SARS-CoV-2.

Keywords: B cell; COVID-19; Epitope; MHC-I; SARS-CoV-2; Structural proteins; T cell.