tetano
Editor, Senior Moderator
Medicine (Baltimore)
. 2021 Feb 19;100(7):e24668.
doi: 10.1097/MD.0000000000024668.
Very fast-progressive pulmonary opacities and high inflammatory factors levels are associated with decease of young Coronavirus Disease 2019 patients
Qiang Zhang[SUP] 1 [/SUP], Ying Xiong[SUP] 2 [/SUP], Ting Wu[SUP] 3 [/SUP], Wenzhen Zhu[SUP] 2 [/SUP]
Affiliations
Abstract
We aimed to retrospectively analyze the clinical and computed tomography (CT) characteristics of young adults with Coronavirus Disease 2019 (COVID-19) pneumonia who were critically ill and to identify the features associated with non-survival.Thirty-eight COVID-19 patients (20-45 years old, 28 men) who had been admitted in the intensive care unit were included, including 18 non-survivors (group 1) and 20 survivors (group 2). Their clinical characteristics and initial and follow-up CT were compared between groups.In group 1, the days from illness onset to death were 21.1 ? 10.3 days; 7 patients had underlying comorbidities. At admission, group 1 exhibited higher serum ferritin and interleukin-6 (IL-6) levels (1142.6 ? 242.4 mg/L and 33.8 ? 18.6 mmol/L) compared with group 2 (728.3 ? 150.9 mg/L and 15.2 ? 6.9 mmol/L, P < .01). Group 1 exhibited more rapidly progressive opacities and consolidation in follow-up CT (16.7 ? 3.1 scores, 15.7 ? 3.1 segments) than group 2 (11.4 ? 4.0 scores, 10.3 ? 4.6 segments, P < .01). The oxygenation index was lower (87.6 ? 19.2 vs 99.1 ? 20.4 mm Hg) and the mechanical ventilation duration was longer (14.7 ? 6.9 vs 9.7 ? 3.7 days) in group 1 compare with group 2 (P < .01).Compared with the survivors, the non-survivors showed higher serum ferritin and IL-6 levels, more rapidly progressive opacities in CT, lower oxygenation index, and longer mechanical ventilation durations. Special attention to ferritin/IL-6 levels and oxygenation index as well as early CT application and timely reexaminations are important to identify the individuals who may be at risk of becoming critically ill.
. 2021 Feb 19;100(7):e24668.
doi: 10.1097/MD.0000000000024668.
Very fast-progressive pulmonary opacities and high inflammatory factors levels are associated with decease of young Coronavirus Disease 2019 patients
Qiang Zhang[SUP] 1 [/SUP], Ying Xiong[SUP] 2 [/SUP], Ting Wu[SUP] 3 [/SUP], Wenzhen Zhu[SUP] 2 [/SUP]
Affiliations
- PMID: 33607804
- DOI: 10.1097/MD.0000000000024668
Abstract
We aimed to retrospectively analyze the clinical and computed tomography (CT) characteristics of young adults with Coronavirus Disease 2019 (COVID-19) pneumonia who were critically ill and to identify the features associated with non-survival.Thirty-eight COVID-19 patients (20-45 years old, 28 men) who had been admitted in the intensive care unit were included, including 18 non-survivors (group 1) and 20 survivors (group 2). Their clinical characteristics and initial and follow-up CT were compared between groups.In group 1, the days from illness onset to death were 21.1 ? 10.3 days; 7 patients had underlying comorbidities. At admission, group 1 exhibited higher serum ferritin and interleukin-6 (IL-6) levels (1142.6 ? 242.4 mg/L and 33.8 ? 18.6 mmol/L) compared with group 2 (728.3 ? 150.9 mg/L and 15.2 ? 6.9 mmol/L, P < .01). Group 1 exhibited more rapidly progressive opacities and consolidation in follow-up CT (16.7 ? 3.1 scores, 15.7 ? 3.1 segments) than group 2 (11.4 ? 4.0 scores, 10.3 ? 4.6 segments, P < .01). The oxygenation index was lower (87.6 ? 19.2 vs 99.1 ? 20.4 mm Hg) and the mechanical ventilation duration was longer (14.7 ? 6.9 vs 9.7 ? 3.7 days) in group 1 compare with group 2 (P < .01).Compared with the survivors, the non-survivors showed higher serum ferritin and IL-6 levels, more rapidly progressive opacities in CT, lower oxygenation index, and longer mechanical ventilation durations. Special attention to ferritin/IL-6 levels and oxygenation index as well as early CT application and timely reexaminations are important to identify the individuals who may be at risk of becoming critically ill.