tetano
Editor, Senior Moderator
Medicine (Baltimore)
. 2022 Sep 2;101(35):e30464.
doi: 10.1097/MD.0000000000030464.
Anti-N-methyl-D-aspartate receptor encephalitis after coronavirus disease 2019: A case report and literature review
Hyesun Lee[SUP] 1 [/SUP], Jong Hyun Jeon, Hojin Choi, Seong-Ho Koh, Kyu-Yong Lee, Young Joo Lee, Hyuk Sung Kwon
Affiliations
Abstract
Rationale: Coronavirus disease 2019 (COVID-19) has become a global pandemic and COVID-19-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may occur through an immune-mediated pathomechanism.
Patient concerns: A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms.
Diagnosis: The patient was diagnosed with anti-NMDAR encephalitis.
Intervention: Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma.
Outcomes: The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms.
Lessons: Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.
. 2022 Sep 2;101(35):e30464.
doi: 10.1097/MD.0000000000030464.
Anti-N-methyl-D-aspartate receptor encephalitis after coronavirus disease 2019: A case report and literature review
Hyesun Lee[SUP] 1 [/SUP], Jong Hyun Jeon, Hojin Choi, Seong-Ho Koh, Kyu-Yong Lee, Young Joo Lee, Hyuk Sung Kwon
Affiliations
- PMID: 36107550
- DOI: 10.1097/MD.0000000000030464
Abstract
Rationale: Coronavirus disease 2019 (COVID-19) has become a global pandemic and COVID-19-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis may occur through an immune-mediated pathomechanism.
Patient concerns: A 21-year-old woman with a history of COVID-19 presented to our hospital with memory decline and psychiatric symptoms.
Diagnosis: The patient was diagnosed with anti-NMDAR encephalitis.
Intervention: Intravenous methylprednisolone (1 g/day over 5 days) followed by immunoglobulin (0.4 g/kg/day over 5 days) were administered. The patient underwent laparoscopic salpingo-oophorectomy to remove an ovarian teratoma.
Outcomes: The patient was discharged with sequelae of short-term memory impairment, without other neuropsychiatric symptoms.
Lessons: Cases of previously reported anti-NMDAR encephalitis with COVID-19 were reviewed and compared with the present case. Clinicians should be aware of the occurrence of anti-NMDAR encephalitis in patients who present with neuropsychiatric complaints during or after exposure to COVID-19. Further studies are required to determine the causal relationship between the 2 diseases and predict the prognosis of anti-NMDAR encephalitis after COVID-19 exposure.