tetano
Editor, Senior Moderator
Mediators Inflamm
. 2021 Oct 5;2021:2911578.
doi: 10.1155/2021/2911578. eCollection 2021.
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
Sagar Vyavahare[SUP] 1 [/SUP], Sandeep Kumar[SUP] 1 [/SUP], Nicholas Cantu[SUP] 2 [/SUP], Ravindra Kolhe[SUP] 3 [/SUP], Wendy B Bollag[SUP] 4 5 [/SUP], Meghan E McGee-Lawrence[SUP] 1 5 [/SUP], William D Hill[SUP] 6 [/SUP], Mark W Hamrick[SUP] 1 5 [/SUP], Carlos M Isales[SUP] 2 5 [/SUP], Sadanand Fulzele[SUP] 1 2 5 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.
. 2021 Oct 5;2021:2911578.
doi: 10.1155/2021/2911578. eCollection 2021.
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview
Sagar Vyavahare[SUP] 1 [/SUP], Sandeep Kumar[SUP] 1 [/SUP], Nicholas Cantu[SUP] 2 [/SUP], Ravindra Kolhe[SUP] 3 [/SUP], Wendy B Bollag[SUP] 4 5 [/SUP], Meghan E McGee-Lawrence[SUP] 1 5 [/SUP], William D Hill[SUP] 6 [/SUP], Mark W Hamrick[SUP] 1 5 [/SUP], Carlos M Isales[SUP] 2 5 [/SUP], Sadanand Fulzele[SUP] 1 2 5 [/SUP]
Affiliations
- PMID: 34621138
- PMCID: PMC8492288
- DOI: 10.1155/2021/2911578
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.