tetano
Editor, Senior Moderator
Mediators Inflamm
. 2020 Nov 25;2020:2914275.
doi: 10.1155/2020/2914275. eCollection 2020.
Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients
Maria Martinez-Urbistondo[SUP] 1 [/SUP], Alberto Mora-Vargas[SUP] 1 [/SUP], Esther Exp?sito-Palomo[SUP] 1 [/SUP], Raquel Castej?n[SUP] 1 [/SUP], M Jes?s Citores[SUP] 1 [/SUP], Silvia Rosado[SUP] 1 [/SUP], Carmen de Mendoza[SUP] 1 [/SUP], Isolina Ba?os[SUP] 1 [/SUP], Ana Fern?ndez-Cruz[SUP] 1 [/SUP], Lidia Daimiel[SUP] 2 [/SUP], Rodrigo San-Crist?bal[SUP] 2 [/SUP], Juan Antonio Vargas[SUP] 1 [/SUP], J Alfredo Martinez[SUP] 2 3 [/SUP]
Affiliations
Abstract
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a "cytokine storm."
Objective: The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients.
Conclusion: IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.
. 2020 Nov 25;2020:2914275.
doi: 10.1155/2020/2914275. eCollection 2020.
Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients
Maria Martinez-Urbistondo[SUP] 1 [/SUP], Alberto Mora-Vargas[SUP] 1 [/SUP], Esther Exp?sito-Palomo[SUP] 1 [/SUP], Raquel Castej?n[SUP] 1 [/SUP], M Jes?s Citores[SUP] 1 [/SUP], Silvia Rosado[SUP] 1 [/SUP], Carmen de Mendoza[SUP] 1 [/SUP], Isolina Ba?os[SUP] 1 [/SUP], Ana Fern?ndez-Cruz[SUP] 1 [/SUP], Lidia Daimiel[SUP] 2 [/SUP], Rodrigo San-Crist?bal[SUP] 2 [/SUP], Juan Antonio Vargas[SUP] 1 [/SUP], J Alfredo Martinez[SUP] 2 3 [/SUP]
Affiliations
- PMID: 33273888
- PMCID: PMC7695993
- DOI: 10.1155/2020/2914275
Abstract
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a "cytokine storm."
Objective: The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients.
Conclusion: IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.