tetano
Editor, Senior Moderator
Med Mycol Case Rep
. 2022 Mar;35:9-14.
doi: 10.1016/j.mmcr.2021.12.002. Epub 2021 Dec 16.
COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature
Arghadip Samaddar[SUP] 1 [/SUP], Jyoti Diwakar[SUP] 1 [/SUP], Priya Krishnan[SUP] 1 [/SUP], H B Veena Kumari[SUP] 1 [/SUP], M Kavya[SUP] 1 [/SUP], Subhas Konar[SUP] 2 [/SUP], Dinesh A Sharma[SUP] 3 [/SUP], B N Nandeesh[SUP] 4 [/SUP], Aditi Goyal[SUP] 4 [/SUP], S Nagarathna[SUP] 1 [/SUP]
Affiliations
Abstract
We report the first case of Coronavirus Disease 2019 (COVID-19)-associated brain abscess caused by a rare Trichosporon species, T. dohaense. The patient was a known diabetic and had received systemic corticosteroids for the treatment of COVID-19. He underwent craniotomy and evacuation of abscess. The pus aspirate grew a basidiomycetous yeast, morphologically resembling Trichosporon species. The isolate was initially misidentified by VITEK® MS due to lack of mass spectral database of T. dohaense. Accurate identification was achieved by internal transcribed spacer-directed panfungal polymerase chain reaction. The patient had a favorable outcome following surgical intervention and antifungal therapy.
Keywords: Brain abscess; COVID-19; Internal transcribed spacer; MALDI-TOF MS; MALDI-TOF MS, Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Trichosporon dohaense.
. 2022 Mar;35:9-14.
doi: 10.1016/j.mmcr.2021.12.002. Epub 2021 Dec 16.
COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature
Arghadip Samaddar[SUP] 1 [/SUP], Jyoti Diwakar[SUP] 1 [/SUP], Priya Krishnan[SUP] 1 [/SUP], H B Veena Kumari[SUP] 1 [/SUP], M Kavya[SUP] 1 [/SUP], Subhas Konar[SUP] 2 [/SUP], Dinesh A Sharma[SUP] 3 [/SUP], B N Nandeesh[SUP] 4 [/SUP], Aditi Goyal[SUP] 4 [/SUP], S Nagarathna[SUP] 1 [/SUP]
Affiliations
- PMID: 34931159
- PMCID: PMC8674111
- DOI: 10.1016/j.mmcr.2021.12.002
Abstract
We report the first case of Coronavirus Disease 2019 (COVID-19)-associated brain abscess caused by a rare Trichosporon species, T. dohaense. The patient was a known diabetic and had received systemic corticosteroids for the treatment of COVID-19. He underwent craniotomy and evacuation of abscess. The pus aspirate grew a basidiomycetous yeast, morphologically resembling Trichosporon species. The isolate was initially misidentified by VITEK® MS due to lack of mass spectral database of T. dohaense. Accurate identification was achieved by internal transcribed spacer-directed panfungal polymerase chain reaction. The patient had a favorable outcome following surgical intervention and antifungal therapy.
Keywords: Brain abscess; COVID-19; Internal transcribed spacer; MALDI-TOF MS; MALDI-TOF MS, Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; Trichosporon dohaense.