tetano
Editor, Senior Moderator
Med Microbiol Immunol
. 2023 Jul 25.
doi: 10.1007/s00430-023-00776-7. Online ahead of print. COVID-19 recurrence is related to disease-early profile T cells while detection of anti-S1 IgG is related to multifunctional T cells
Camilla Natália O Santos[SUP] 1 2 [/SUP], Gustavo C Caldas[SUP] 1 3 [/SUP], Fabricia A de Oliveira[SUP] 1 [/SUP], Angela Maria da Silva[SUP] 1 2 3 [/SUP], João S da Silva[SUP] 4 [/SUP], Ricardo Luís L da Silva[SUP] 1 5 [/SUP], Amélia R de Jesus[SUP] 1 2 3 6 [/SUP], Lucas S Magalhães[SUP] #[/SUP][SUP] 7 8 9 [/SUP], Roque P de Almeida[SUP] #[/SUP][SUP] 1 2 3 6 [/SUP]
Affiliations
COVID-19 is caused by SARS-CoV-2 infection and leads from asymptomatic to severe outcomes. The recurrence of the COVID-19 has been described, however, mechanisms involved remains unclear. Thus, the work aimed to investigate the role of multifunctional T cells in patients with recurrent COVID-19. We evaluated clinical characteristics, presence of anti-S1 and anti-Nucleocapsid IgG in patients' sera, and multifunctional T cells (for IFN-γ, IL-2, and TNF-α) in patients with multiple episodes of COVID-19 and controls. Data demonstrate that patients with recurrent COVID-19 have a T cell pattern predominantly related to IFN-γ production. Also, patients with COVID-19 history and absence of anti-S1 IgG had lower levels of CD4+ IFN + IL-2 + TNF + T cells independently of number of disease episodes. Complementary, vaccination changed the patterns of T cells phenotypes and induced IgG seroconversion, despite not induce higher levels of multifunctional T cells in all patients. In conclusion, the data suggest that recurrent disease is related to early-disease T cell profile and absence of anti-S1 IgG is related to lower multifunctional CD4 T cell response, what suggests possibility of new episodes of COVID-19 in these patients.
Keywords: Coronavirus disease 2019; Multifunctional T cell; SARS-CoV-2; T cells; Viral antibodies.
. 2023 Jul 25.
doi: 10.1007/s00430-023-00776-7. Online ahead of print. COVID-19 recurrence is related to disease-early profile T cells while detection of anti-S1 IgG is related to multifunctional T cells
Camilla Natália O Santos[SUP] 1 2 [/SUP], Gustavo C Caldas[SUP] 1 3 [/SUP], Fabricia A de Oliveira[SUP] 1 [/SUP], Angela Maria da Silva[SUP] 1 2 3 [/SUP], João S da Silva[SUP] 4 [/SUP], Ricardo Luís L da Silva[SUP] 1 5 [/SUP], Amélia R de Jesus[SUP] 1 2 3 6 [/SUP], Lucas S Magalhães[SUP] #[/SUP][SUP] 7 8 9 [/SUP], Roque P de Almeida[SUP] #[/SUP][SUP] 1 2 3 6 [/SUP]
Affiliations
- PMID: 37488347
- DOI: 10.1007/s00430-023-00776-7
COVID-19 is caused by SARS-CoV-2 infection and leads from asymptomatic to severe outcomes. The recurrence of the COVID-19 has been described, however, mechanisms involved remains unclear. Thus, the work aimed to investigate the role of multifunctional T cells in patients with recurrent COVID-19. We evaluated clinical characteristics, presence of anti-S1 and anti-Nucleocapsid IgG in patients' sera, and multifunctional T cells (for IFN-γ, IL-2, and TNF-α) in patients with multiple episodes of COVID-19 and controls. Data demonstrate that patients with recurrent COVID-19 have a T cell pattern predominantly related to IFN-γ production. Also, patients with COVID-19 history and absence of anti-S1 IgG had lower levels of CD4+ IFN + IL-2 + TNF + T cells independently of number of disease episodes. Complementary, vaccination changed the patterns of T cells phenotypes and induced IgG seroconversion, despite not induce higher levels of multifunctional T cells in all patients. In conclusion, the data suggest that recurrent disease is related to early-disease T cell profile and absence of anti-S1 IgG is related to lower multifunctional CD4 T cell response, what suggests possibility of new episodes of COVID-19 in these patients.
Keywords: Coronavirus disease 2019; Multifunctional T cell; SARS-CoV-2; T cells; Viral antibodies.