tetano
Editor, Senior Moderator
Med Hypotheses
. 2020 Oct 1;145:110330.
doi: 10.1016/j.mehy.2020.110330. Online ahead of print.
Viral replication of SARS-CoV-2 could be self-limitative - The role of the renin-angiotensin system on COVID-19 pathophysiology
Vinicius Novaes Rocha[SUP] 1 [/SUP]
Affiliations
Abstract
Currently, the world is suffering with one of the biggest pandemics of recent history. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) is provoking devastating consequences on economic and social fields throughout all continents. Therefore, pathophysiological knowledge about COVID-19 is imperative for better planning of preventive measures, diagnosis, and therapeutics of the disease. Based on previous studies, this work proposes new hypothesis related to the role of the renin-angiotensin system on the pathophysiology of COVID-19, and its purpose is to enrich the discussion and to offer alternative ways for experimental and clinical studies aiming at the formulation of new diagnosis and/or treatment methods.
Keywords: ACE2; COVID-19; Renin-angiotensin system; SARS-CoV-2.
. 2020 Oct 1;145:110330.
doi: 10.1016/j.mehy.2020.110330. Online ahead of print.
Viral replication of SARS-CoV-2 could be self-limitative - The role of the renin-angiotensin system on COVID-19 pathophysiology
Vinicius Novaes Rocha[SUP] 1 [/SUP]
Affiliations
- PMID: 33049594
- DOI: 10.1016/j.mehy.2020.110330
Abstract
Currently, the world is suffering with one of the biggest pandemics of recent history. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) is provoking devastating consequences on economic and social fields throughout all continents. Therefore, pathophysiological knowledge about COVID-19 is imperative for better planning of preventive measures, diagnosis, and therapeutics of the disease. Based on previous studies, this work proposes new hypothesis related to the role of the renin-angiotensin system on the pathophysiology of COVID-19, and its purpose is to enrich the discussion and to offer alternative ways for experimental and clinical studies aiming at the formulation of new diagnosis and/or treatment methods.
Keywords: ACE2; COVID-19; Renin-angiotensin system; SARS-CoV-2.