tetano
Editor, Senior Moderator
Med Hypotheses
. 2020 Jun 1;144:109947.
doi: 10.1016/j.mehy.2020.109947. Online ahead of print.
Nebulized Lidocaine in COVID-19, An Hypothesis
Ziad A Ali[SUP] 1 [/SUP], Rif S El-Mallakh[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients' lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
Keywords: Anti-inflammatories; COVID-19; Cytokine-storm; Lidocaine; SARS-CoV-2.
. 2020 Jun 1;144:109947.
doi: 10.1016/j.mehy.2020.109947. Online ahead of print.
Nebulized Lidocaine in COVID-19, An Hypothesis
Ziad A Ali[SUP] 1 [/SUP], Rif S El-Mallakh[SUP] 2 [/SUP]
Affiliations
- PMID: 32505070
- DOI: 10.1016/j.mehy.2020.109947
Abstract
Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients' lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
Keywords: Anti-inflammatories; COVID-19; Cytokine-storm; Lidocaine; SARS-CoV-2.