tetano
Editor, Senior Moderator
Med Hypotheses
. 2020 Jul 8;143:110080.
doi: 10.1016/j.mehy.2020.110080. Online ahead of print.
Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J [SUB]2[/SUB]) for effective treatment and reduction in the death toll
Shakeel Shahzad[SUP] 1 [/SUP], Mark Willcox[SUP] 2 [/SUP]
Affiliations
Abstract
Coronaviruses including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, also known as 2019-nCoV especially in China) replicate and divide in host cells. During this they are partly hidden from the innate immune responses although inflammatory consequences of viral replication still occur. We propose that anti-inflammatory antiviral prostaglandins may not only restrict viral replication but also prevent inflammatory responses in the lungs and other vital organs that are known to be part of the immuno-pathogenesis of coronavirus disease-19 (COVID-19). The combination of anti-inflammatory antiviral prostaglandins with interferons may lead to the clearance of viruses inside growth-restricted infected cells. However, further experimental studies and clinical trials should be conducted to evaluate the safety and efficacy of these possible therapies.
Keywords: Anti-inflammatory and anti-viral prostaglandin; Immuno-pathology; SARS-CoV-2.
. 2020 Jul 8;143:110080.
doi: 10.1016/j.mehy.2020.110080. Online ahead of print.
Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J [SUB]2[/SUB]) for effective treatment and reduction in the death toll
Shakeel Shahzad[SUP] 1 [/SUP], Mark Willcox[SUP] 2 [/SUP]
Affiliations
- PMID: 32683221
- DOI: 10.1016/j.mehy.2020.110080
Abstract
Coronaviruses including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, also known as 2019-nCoV especially in China) replicate and divide in host cells. During this they are partly hidden from the innate immune responses although inflammatory consequences of viral replication still occur. We propose that anti-inflammatory antiviral prostaglandins may not only restrict viral replication but also prevent inflammatory responses in the lungs and other vital organs that are known to be part of the immuno-pathogenesis of coronavirus disease-19 (COVID-19). The combination of anti-inflammatory antiviral prostaglandins with interferons may lead to the clearance of viruses inside growth-restricted infected cells. However, further experimental studies and clinical trials should be conducted to evaluate the safety and efficacy of these possible therapies.
Keywords: Anti-inflammatory and anti-viral prostaglandin; Immuno-pathology; SARS-CoV-2.