tetano
Editor, Senior Moderator
Med Clin (Engl Ed)
. 2022 Aug 1.
doi: 10.1016/j.medcle.2022.07.010. Online ahead of print.
Influence of smoking history on the progression of hospitalised COVID-19 positive patients: results from the SEMI-COVID-19 registry
María Sierra Navas Alcántara[SUP] 1 [/SUP], Lorena Montero Rivas[SUP] 1 [/SUP], María Esther Guisado Espartero[SUP] 1 [/SUP], Manuel Rubio-Rivas[SUP] 2 [/SUP], Blanca Ayuso García[SUP] 3 [/SUP], Francisco Moreno Martinez[SUP] 4 [/SUP], Cristina Ausín García[SUP] 5 [/SUP], María Luisa Taboada Martínez[SUP] 6 [/SUP], Francisco Arnalich Fernández[SUP] 7 [/SUP], Raúl Martínez Murgui[SUP] 8 [/SUP], Sonia Molinos Castro[SUP] 9 [/SUP], Maria Esther Ramos Muñoz[SUP] 10 [/SUP], Mar Fernández-Garcés[SUP] 11 [/SUP], Mari Cruz Carreño Hernandez[SUP] 12 [/SUP], Gema María García García[SUP] 13 [/SUP], Nuria Vázquez Piqueras[SUP] 14 [/SUP], Jesica Abadía-Otero[SUP] 15 [/SUP], Lourdes Lajara Villar[SUP] 16 [/SUP], Cristina Salazar Monteiro[SUP] 17 [/SUP], María de Los Reyes Pascual Pérez[SUP] 18 [/SUP], Santiago Perez-Martin[SUP] 19 [/SUP], Javier Collado-Aliaga[SUP] 20 [/SUP], Juan-Miguel Antón-Santos[SUP] 21 [/SUP], Carlos Lumbreras-Bermejo[SUP] 3 [/SUP], en nombre del grupo SEMI-COVID19
Affiliations
Abstract
in English, Spanish
Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).
Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.
Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 (59.6-78.0 years)), more frequently male (80.3%) and with higher Charlson index (4 (2-6)) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs 16.4%) and readmission at one month (5.8 vs 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.
Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; hospitalized; mortality; smoking.
. 2022 Aug 1.
doi: 10.1016/j.medcle.2022.07.010. Online ahead of print.
Influence of smoking history on the progression of hospitalised COVID-19 positive patients: results from the SEMI-COVID-19 registry
María Sierra Navas Alcántara[SUP] 1 [/SUP], Lorena Montero Rivas[SUP] 1 [/SUP], María Esther Guisado Espartero[SUP] 1 [/SUP], Manuel Rubio-Rivas[SUP] 2 [/SUP], Blanca Ayuso García[SUP] 3 [/SUP], Francisco Moreno Martinez[SUP] 4 [/SUP], Cristina Ausín García[SUP] 5 [/SUP], María Luisa Taboada Martínez[SUP] 6 [/SUP], Francisco Arnalich Fernández[SUP] 7 [/SUP], Raúl Martínez Murgui[SUP] 8 [/SUP], Sonia Molinos Castro[SUP] 9 [/SUP], Maria Esther Ramos Muñoz[SUP] 10 [/SUP], Mar Fernández-Garcés[SUP] 11 [/SUP], Mari Cruz Carreño Hernandez[SUP] 12 [/SUP], Gema María García García[SUP] 13 [/SUP], Nuria Vázquez Piqueras[SUP] 14 [/SUP], Jesica Abadía-Otero[SUP] 15 [/SUP], Lourdes Lajara Villar[SUP] 16 [/SUP], Cristina Salazar Monteiro[SUP] 17 [/SUP], María de Los Reyes Pascual Pérez[SUP] 18 [/SUP], Santiago Perez-Martin[SUP] 19 [/SUP], Javier Collado-Aliaga[SUP] 20 [/SUP], Juan-Miguel Antón-Santos[SUP] 21 [/SUP], Carlos Lumbreras-Bermejo[SUP] 3 [/SUP], en nombre del grupo SEMI-COVID19
Affiliations
- PMID: 35935808
- PMCID: PMC9339973
- DOI: 10.1016/j.medcle.2022.07.010
Abstract
in English, Spanish
Introduction: Smoking can play a key role in SARS-CoV-2 infection and in the course of the disease. Previous studies have conflicting or inconclusive results on the prevalence of smoking and the severity of the coronavirus disease (COVID-19).
Methods: Observational, multicenter, retrospective cohort study of 14,260 patients admitted for COVID-19 in Spanish hospitals between February and September 2020. Their clinical characteristics were recorded and the patients were classified into a smoking group (active or former smokers) or a non-smoking group (never smokers). The patients were followed up to one month after discharge. Differences between groups were analyzed. A multivariate logistic regression and Kapplan Meier curves analyzed the relationship between smoking and in-hospital mortality.
Results: The median age was 68.6 (55.8-79.1) years, with 57.7% of males. Smoking patients were older (69.9 (59.6-78.0 years)), more frequently male (80.3%) and with higher Charlson index (4 (2-6)) than non-smoking patients. Smoking patients presented a worse evolution, with a higher rate of admission to the intensive care unit (ICU) (10.4 vs 8.1%), higher in-hospital mortality (22.5 vs 16.4%) and readmission at one month (5.8 vs 4.0%) than in non-smoking patients. After multivariate analysis, smoking remained associated with these events.
Conclusions: Active or past smoking is an independent predictor of poor prognosis in patients with COVID-19. It is associated with higher ICU admissions and in-hospital mortality.
Keywords: COVID-19; SARS-CoV-2; hospitalized; mortality; smoking.