tetano
Editor, Senior Moderator
Med Clin (Barc)
. 2021 May 7;S0025-7753(21)00240-2.
doi: 10.1016/j.medcli.2021.03.027. Online ahead of print.
Susceptibility and risk of SARS-COV-2 infection among middle-aged and older adults in Tarragona area, Spain
[Article in English, Spanish]
Eva M Satué-Gracia[SUP] 1 [/SUP], Angel Vila-Córcoles[SUP] 2 [/SUP], Cinta de Diego-Cabanes[SUP] 3 [/SUP], Angel Vila-Rovira[SUP] 4 [/SUP], Cristina Torrente-Fraga[SUP] 5 [/SUP], Frederic Gómez-Bertomeu[SUP] 6 [/SUP], Imma Hospital-Guardiola[SUP] 7 [/SUP], Olga Ochoa-Gondar[SUP] 8 [/SUP], Francisco Martín-Luján[SUP] 2 [/SUP]
Affiliations
Abstract
Objective: To analyse susceptibility/risk of suffering COVID-19 among adults with distinct underlying medical conditions.
Methods: Population-based cohort study involving 79,083 individuals ≥50 years old in Tarragona (Southern Catalonia, Spain). Baseline cohort characteristics (demographic, pre-existing comorbidities, chronic medications and vaccinations history) were established at study start (01/03/2020) and primary outcome was laboratory-confirmed COVID-19 occurred among cohort members throughout 01/03/2020-30/06/2020. Risk of suffering COVID-19 was evaluated by Cox regression, estimating multivariable hazard ratios (HRs) adjusted for age/sex and pre-existing comorbidities.
Results: Across study period, 536 laboratory-confirmed COVID-19 cases were observed (mean incidence: 39.5 cases per 100,000 persons-week). In multivariable-analysis, increasing age/years (HR: 1.01; 95% CI: 1.00-1.02), nursing-home (HR: 20.19; 95% CI: 15.98-25.51), neurological disease (HR: 1.35; 95% CI: 1.03-1.77), taking diuretics (HR: 1.39; 95% CI: 1.10-1.75), antiplatelet (HR: 1.36; 95% CI: 1.05-1.76) and benzodiazepines (HR: 1.24; 95% CI: 1.00-1.53) increased risk; conversely, taking angiotensin-converting-enzyme inhibitors (HR: 0.78; 95% CI: 0.61-1.00), angiotensin-receptor-blockers (HR: 0.70; 95%CI: 0.51-0.96) and statins (HR: 0.75; 95% CI: 0.58-0.96) were associated with reduced risk. Among community-dwelling individuals, pre-existing cancer, renal and cardiac disease appeared also related with an increased risk, whereas influenza vaccination was associated with reduced risk.
Conclusion: In a setting with relatively low incidence of COVID-19 across the first wave of pandemic period, increasing age, nursing-home residence and multiple comorbidities appear predisposing for COVID-19 among middle-aged/older adults. Conversely, statins, angiotensin-receptor blockers/inhibitors and influenza vaccination were related with decreased risk.
Keywords: COVID-19; Coronavirus; Incidence; Incidencia; Riesgo; Risk; SARS-COV-2; SARS-CoV-2.
. 2021 May 7;S0025-7753(21)00240-2.
doi: 10.1016/j.medcli.2021.03.027. Online ahead of print.
Susceptibility and risk of SARS-COV-2 infection among middle-aged and older adults in Tarragona area, Spain
[Article in English, Spanish]
Eva M Satué-Gracia[SUP] 1 [/SUP], Angel Vila-Córcoles[SUP] 2 [/SUP], Cinta de Diego-Cabanes[SUP] 3 [/SUP], Angel Vila-Rovira[SUP] 4 [/SUP], Cristina Torrente-Fraga[SUP] 5 [/SUP], Frederic Gómez-Bertomeu[SUP] 6 [/SUP], Imma Hospital-Guardiola[SUP] 7 [/SUP], Olga Ochoa-Gondar[SUP] 8 [/SUP], Francisco Martín-Luján[SUP] 2 [/SUP]
Affiliations
- PMID: 34074472
- DOI: 10.1016/j.medcli.2021.03.027
Abstract
Objective: To analyse susceptibility/risk of suffering COVID-19 among adults with distinct underlying medical conditions.
Methods: Population-based cohort study involving 79,083 individuals ≥50 years old in Tarragona (Southern Catalonia, Spain). Baseline cohort characteristics (demographic, pre-existing comorbidities, chronic medications and vaccinations history) were established at study start (01/03/2020) and primary outcome was laboratory-confirmed COVID-19 occurred among cohort members throughout 01/03/2020-30/06/2020. Risk of suffering COVID-19 was evaluated by Cox regression, estimating multivariable hazard ratios (HRs) adjusted for age/sex and pre-existing comorbidities.
Results: Across study period, 536 laboratory-confirmed COVID-19 cases were observed (mean incidence: 39.5 cases per 100,000 persons-week). In multivariable-analysis, increasing age/years (HR: 1.01; 95% CI: 1.00-1.02), nursing-home (HR: 20.19; 95% CI: 15.98-25.51), neurological disease (HR: 1.35; 95% CI: 1.03-1.77), taking diuretics (HR: 1.39; 95% CI: 1.10-1.75), antiplatelet (HR: 1.36; 95% CI: 1.05-1.76) and benzodiazepines (HR: 1.24; 95% CI: 1.00-1.53) increased risk; conversely, taking angiotensin-converting-enzyme inhibitors (HR: 0.78; 95% CI: 0.61-1.00), angiotensin-receptor-blockers (HR: 0.70; 95%CI: 0.51-0.96) and statins (HR: 0.75; 95% CI: 0.58-0.96) were associated with reduced risk. Among community-dwelling individuals, pre-existing cancer, renal and cardiac disease appeared also related with an increased risk, whereas influenza vaccination was associated with reduced risk.
Conclusion: In a setting with relatively low incidence of COVID-19 across the first wave of pandemic period, increasing age, nursing-home residence and multiple comorbidities appear predisposing for COVID-19 among middle-aged/older adults. Conversely, statins, angiotensin-receptor blockers/inhibitors and influenza vaccination were related with decreased risk.
Keywords: COVID-19; Coronavirus; Incidence; Incidencia; Riesgo; Risk; SARS-COV-2; SARS-CoV-2.