tetano
Editor, Senior Moderator
Med Clin (Barc)
. 2020 May 15;S0025-7753(20)30183-4.
doi: 10.1016/j.medcli.2020.01.030. Online ahead of print.
Effect of Vaccination on the Prevention of Influenza-Related Severe Illness in Adults Attended in a Third Level Hospital During the 2017-2018 Epidemic Season
[Article in English, Spanish]
Guillermo Mena[SUP] 1 [/SUP], Irma Casas[SUP] 2 [/SUP], Cristina Prat[SUP] 3 [/SUP], Cristina Casa?[SUP] 4 [/SUP], Mar?a Esteve[SUP] 1 [/SUP], Agust?n Urrutia[SUP] 5 [/SUP], Josep-Maria M?dol[SUP] 6 [/SUP]
Affiliations
Abstract
Objectives: The objective of this research was to evaluate the effect of influenza vaccination on the prevention of influenza-related severe cases in adults treated in a third-level hospital during the 2017-2018 epidemic season.
Methodology: A descriptive analysis was performed on the entire population of subjects with a laboratory-confirmed influenza test during the 2017-2018 season. A severe case was defined as a patient treated in one of the Intensive Care Units (ICUs) and/or death. The effect of the vaccine on the adult population was determined by multivariate logistic regression analysis.
Results: Between epidemiological weeks 44/2017 and 19/2018, the hospital's laboratory detected 706 positive samples for influenza virus. Of the 551 confirmed patients aged 18 years or older, forty-three were admitted to one of the ICUs, and 26 died during admission. The explanatory multivariate model has shown that flu vaccination prior to or during the epidemic season was a protective factor for the development of severity [OR:0.27 (0.11-0.65, p=0.004)], adjusted by age [OR: 1.03 (1.01-1.06), p=.04], sex, type of virus (H1N1-pdm09, H3N2 or B virus), Chronic Complex Patient index or Advanced Chronic Disease index.
Conclussions: Influenza vaccination is a protective factor against the development of severity associated with influenza infection in a season when vaccination did not contain the virus with higher epidemic circulation among the population. Flu vaccination should be recommended annually following the guidelines established by the health authorities.
Keywords: Efectividad; Effectiveness; Epidemiologia; Epidemiology; Flu; Gravedad; Gripe; Hospital; Severity; Vaccine; Vacuna.
. 2020 May 15;S0025-7753(20)30183-4.
doi: 10.1016/j.medcli.2020.01.030. Online ahead of print.
Effect of Vaccination on the Prevention of Influenza-Related Severe Illness in Adults Attended in a Third Level Hospital During the 2017-2018 Epidemic Season
[Article in English, Spanish]
Guillermo Mena[SUP] 1 [/SUP], Irma Casas[SUP] 2 [/SUP], Cristina Prat[SUP] 3 [/SUP], Cristina Casa?[SUP] 4 [/SUP], Mar?a Esteve[SUP] 1 [/SUP], Agust?n Urrutia[SUP] 5 [/SUP], Josep-Maria M?dol[SUP] 6 [/SUP]
Affiliations
- PMID: 32423688
- DOI: 10.1016/j.medcli.2020.01.030
Abstract
Objectives: The objective of this research was to evaluate the effect of influenza vaccination on the prevention of influenza-related severe cases in adults treated in a third-level hospital during the 2017-2018 epidemic season.
Methodology: A descriptive analysis was performed on the entire population of subjects with a laboratory-confirmed influenza test during the 2017-2018 season. A severe case was defined as a patient treated in one of the Intensive Care Units (ICUs) and/or death. The effect of the vaccine on the adult population was determined by multivariate logistic regression analysis.
Results: Between epidemiological weeks 44/2017 and 19/2018, the hospital's laboratory detected 706 positive samples for influenza virus. Of the 551 confirmed patients aged 18 years or older, forty-three were admitted to one of the ICUs, and 26 died during admission. The explanatory multivariate model has shown that flu vaccination prior to or during the epidemic season was a protective factor for the development of severity [OR:0.27 (0.11-0.65, p=0.004)], adjusted by age [OR: 1.03 (1.01-1.06), p=.04], sex, type of virus (H1N1-pdm09, H3N2 or B virus), Chronic Complex Patient index or Advanced Chronic Disease index.
Conclussions: Influenza vaccination is a protective factor against the development of severity associated with influenza infection in a season when vaccination did not contain the virus with higher epidemic circulation among the population. Flu vaccination should be recommended annually following the guidelines established by the health authorities.
Keywords: Efectividad; Effectiveness; Epidemiologia; Epidemiology; Flu; Gravedad; Gripe; Hospital; Severity; Vaccine; Vacuna.