tetano
Editor, Senior Moderator
Med
. 2023 Sep 12;S2666-6340(23)00282-9.
doi: 10.1016/j.medj.2023.08.005. Online ahead of print. A multi-country analysis of COVID-19 hospitalizations by vaccination status
Bronner P Gonçalves[SUP] 1 [/SUP], Waasila Jassat[SUP] 2 [/SUP], Joaquín Baruch[SUP] 3 [/SUP], Madiha Hashmi[SUP] 4 [/SUP], Amanda Rojek[SUP] 3 [/SUP], Abhishek Dasgupta[SUP] 5 [/SUP], Ignacio Martin-Loeches[SUP] 6 [/SUP], Luis Felipe Reyes[SUP] 7 [/SUP], Chiara Piubelli[SUP] 8 [/SUP], Barbara Wanjiru Citarella[SUP] 3 [/SUP], Christiana Kartsonaki[SUP] 9 [/SUP], Benjamin Lefèvre[SUP] 10 [/SUP], José W López Revilla[SUP] 11 [/SUP], Miles Lunn[SUP] 3 [/SUP], Ewen M Harrison[SUP] 12 [/SUP], Moritz U G Kraemer[SUP] 13 [/SUP], Sally Shrapnel[SUP] 14 [/SUP], Peter Horby[SUP] 3 [/SUP], Zeno Bisoffi[SUP] 8 [/SUP], Piero L Olliaro[SUP] 3 [/SUP], Laura Merson[SUP] 3 [/SUP]; ISARIC Clinical Characterisation Group
Collaborators, Affiliations
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.
Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.
Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.
Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.
Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.
Keywords: COVID-19; Translation to population health; comorbidity; descriptive epidemiology; heterogeneity; vaccination.
. 2023 Sep 12;S2666-6340(23)00282-9.
doi: 10.1016/j.medj.2023.08.005. Online ahead of print. A multi-country analysis of COVID-19 hospitalizations by vaccination status
Bronner P Gonçalves[SUP] 1 [/SUP], Waasila Jassat[SUP] 2 [/SUP], Joaquín Baruch[SUP] 3 [/SUP], Madiha Hashmi[SUP] 4 [/SUP], Amanda Rojek[SUP] 3 [/SUP], Abhishek Dasgupta[SUP] 5 [/SUP], Ignacio Martin-Loeches[SUP] 6 [/SUP], Luis Felipe Reyes[SUP] 7 [/SUP], Chiara Piubelli[SUP] 8 [/SUP], Barbara Wanjiru Citarella[SUP] 3 [/SUP], Christiana Kartsonaki[SUP] 9 [/SUP], Benjamin Lefèvre[SUP] 10 [/SUP], José W López Revilla[SUP] 11 [/SUP], Miles Lunn[SUP] 3 [/SUP], Ewen M Harrison[SUP] 12 [/SUP], Moritz U G Kraemer[SUP] 13 [/SUP], Sally Shrapnel[SUP] 14 [/SUP], Peter Horby[SUP] 3 [/SUP], Zeno Bisoffi[SUP] 8 [/SUP], Piero L Olliaro[SUP] 3 [/SUP], Laura Merson[SUP] 3 [/SUP]; ISARIC Clinical Characterisation Group
Collaborators, Affiliations
- PMID: 37738979
- DOI: 10.1016/j.medj.2023.08.005
Background: Individuals vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), when infected, can still develop disease that requires hospitalization. It remains unclear whether these patients differ from hospitalized unvaccinated patients with regard to presentation, coexisting comorbidities, and outcomes.
Methods: Here, we use data from an international consortium to study this question and assess whether differences between these groups are context specific. Data from 83,163 hospitalized COVID-19 patients (34,843 vaccinated, 48,320 unvaccinated) from 38 countries were analyzed.
Findings: While typical symptoms were more often reported in unvaccinated patients, comorbidities, including some associated with worse prognosis in previous studies, were more common in vaccinated patients. Considerable between-country variation in both in-hospital fatality risk and vaccinated-versus-unvaccinated difference in this outcome was observed.
Conclusions: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history.
Funding: This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z, and 220757/Z/20/Z); the Bill & Melinda Gates Foundation (OPP1209135); and the philanthropic support of the donors to the University of Oxford's COVID-19 Research Response Fund (0009109). Additional funders are listed in the "acknowledgments" section.
Keywords: COVID-19; Translation to population health; comorbidity; descriptive epidemiology; heterogeneity; vaccination.